Results 91 to 100 of about 166,756 (292)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Manuscript Success and Choosing a Topic
Successful manuscript writing hinges on careful planning, particularly in selecting a compelling topic. Key steps include journal diligence, template analysis, and drafting. Authors should focus on engaging topics that resonate with editors. Ultimately, effective topic selection enhances the likelihood of publication, leading to a rewarding writing ...
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Névtani Értesítő, 2014 Onomastic manuscripts at the Library of the Department of Hungarian and General Linguistics in Babeş–Bolyai University, Cluj-Napoca, Romania This paper discusses the position of Onomastics in the curriculum of Hungarian higher education in ...
Magdolna Csomortáni
doaj
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Beliefs and practices in health and disease from the Maclagan Manuscripts (1892–1903) [PDF]
, 2014 The Maclagan Manuscripts (1892–1903) are derived from transcriptions of an extensive range of oral traditional narratives collected from a large number of named loci throughout the Highlands and Islands of Scotland, but principally from Argyllshire ...
Turner, Allan. R
core
Methodological Issues in Macro Comparative Research: An Introduction
Journal of World-Systems Research, 2015 This special issue of JWSR is the offspring of an ASA Political Economy of the World System session that I organized in 2007. My thanks to Andrew Jorgenson, co-editor of JWSR, who moderated the session and proposed that I put together a special issue on ...
Jeffrey Kentor
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source