Results 31 to 40 of about 64,361 (214)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Risk Profiling of Ukrainian Banks through Structural-Functional Groups: Evidence from Kohonen Self-Organizing Maps [PDF]
Financial Markets, Institutions and RisksThe growing complexity of banking-sector risk assessment under uncertainty has increased the relevance of data-driven financial risk management, risk-oriented banking supervision, and financial stability monitoring for financial markets, institutions ...
Olena ZARUTSKA, Maksym W. SITNICKІ
doaj +1 more source
A map-based logistic neuron model: an efficient way to obtain many different neural behaviors
BMC Neuroscience, 2014 The KTz neuron model [1-5] is a map with three dynamic variables: the neuron membrane potential (xt), a recovery variable (yt) and a slow adaptive current (zt), given by the following equations: xt+1=tanhxt-Kyt+zt+ItT, yt+1=xt, zt+1=1-δzt-λxt-xR, where δ is related to the refractory period, xR is the reversal ...
Stenzinger, Rafael V +3 more
openaire +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Scientific ReportsThis article presents a novel framework for mean square finite-time synchronization (MSFTSn) and mean square finite-time contractive synchronization (MSFTCSn) of fractional-order stochastic delayed neural networks (FOSDNNs) subject to hybrid control. The
Gokul Palanisamy +3 more
doaj +1 more source