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The application of convolutional neural network to stem cell biology [PDF]
Inflammation and Regeneration, 2019 Induced pluripotent stem cells (iPSC) are one the most prominent innovations of medical research in the last few decades. iPSCs can be easily generated from human somatic cells and have several potential uses in regenerative medicine, disease modeling ...
Shinsuke Yuasa, Yuasa Shinsuke
exaly +5 more sources
Emotion Processing Dysfunction in Alzheimer's Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. [PDF]
Am J Alzheimers Dis Other Demen, 2022 We described behavioral studies to highlight emotional processing deficits in Alzheimer’s disease (AD). The findings suggest prominent deficit in recognizing negative emotions, pronounced effect of positive emotion on enhancing memory, and a critical ...
Chaudhary S +4 more
europepmc +2 more sources
Reliable interpretability of biology-inspired deep neural networks
npj Systems Biology and Applications, 2023 Deep neural networks display impressive performance but suffer from limited interpretability. Biology-inspired deep learning, where the architecture of the computational graph is based on biological knowledge, enables unique interpretability where real ...
Wolfgang Esser‐Skala, N. Fortelny
semanticscholar +4 more sources
The epitranscriptome in stem cell biology and neural development
Neurobiology of Disease, 2020 The blossoming field of epitranscriptomics has recently garnered attention across many fields by findings that chemical modifications on RNA have immense biological consequences.
Caroline Vissers +3 more
semanticscholar +4 more sources
Ancestral glycoprotein hormone-receptor pathway controls growth in C. elegans
Frontiers in Endocrinology, 2023 In vertebrates, thyrostimulin is a highly conserved glycoprotein hormone that, besides thyroid stimulating hormone (TSH), is a potent ligand of the TSH receptor.
Signe Kenis +6 more
doaj +1 more source
A novel retinal ganglion cell quantification tool based on deep learning
Scientific Reports, 2021 Glaucoma is a disease associated with the loss of retinal ganglion cells (RGCs), and remains one of the primary causes of blindness worldwide. Major research efforts are presently directed towards the understanding of disease pathogenesis and the ...
Luca Masin +7 more
doaj +1 more source
Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice
Brain Sciences, 2022 The microbiota-gut-brain axis has attracted significant attention with respect to studying the mechanisms of brain aging; however, the specific connection between gut microbiota and aging remains unclear.
Cuiping Liu +7 more
doaj +1 more source
Biology, 2023 Simple Summary Pessoa postulates that bran anatomy associated with the processing and expression of emotion-laden content, such as the amygdala and limbic cortices, is resource capacity-limited.
K. Clark
semanticscholar +1 more source
TET Enzymes and 5-Hydroxymethylcytosine in Neural Progenitor Cell Biology and Neurodevelopment
Frontiers in Cell and Developmental Biology, 2021 Studies of tissue-specific epigenomes have revealed 5-hydroxymethylcytosine (5hmC) to be a highly enriched and dynamic DNA modification in the metazoan nervous system, inspiring interest in the function of this epigenetic mark in neurodevelopment and ...
Ian C. MacArthur, Meelad M. Dawlaty
semanticscholar +1 more source