Results 1 to 10 of about 777,545 (177)
Ancestral glycoprotein hormone-receptor pathway controls growth in C. elegans
Frontiers in Endocrinology, 2023 In vertebrates, thyrostimulin is a highly conserved glycoprotein hormone that, besides thyroid stimulating hormone (TSH), is a potent ligand of the TSH receptor.
Signe Kenis +6 more
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A novel retinal ganglion cell quantification tool based on deep learning
Scientific Reports, 2021 Glaucoma is a disease associated with the loss of retinal ganglion cells (RGCs), and remains one of the primary causes of blindness worldwide. Major research efforts are presently directed towards the understanding of disease pathogenesis and the ...
Luca Masin +7 more
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Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice
Brain Sciences, 2022 The microbiota-gut-brain axis has attracted significant attention with respect to studying the mechanisms of brain aging; however, the specific connection between gut microbiota and aging remains unclear.
Cuiping Liu +7 more
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Building blocks of consciousness: Revealing the shared, hidden depths of our biological heritage
HTS Teologiese Studies/Theological Studies, 2020 Human consciousness has been a hard problem for thousands of years and, in the course of time, variously interpreted and often too narrowly defined. As a result, the possibility of animal consciousness, sentience or even the possibility that animals can ...
Juri van den Heever, Chris Jones
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Reelin function in neural stem cell biology [PDF]
Proceedings of the National Academy of Sciences, 2002 In the adult brain, neural stem cells (NSC) must migrate to express their neuroplastic potential. The addition of recombinant reelin to human NSC (HNSC) cultures facilitates neuronal retraction in the neurospheroid. Because we detected reelin, α3-integrin receptor subunits, and disabled-1 immunoreactivity in HNSC cultures, it is possible that integrin ...
H M, Kim +8 more
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MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System
Cells, 2021 Neuroinflammation has been put forward as a mechanism triggering axonal regrowth in the mammalian central nervous system (CNS), yet little is known about the underlying cellular and molecular players connecting these two processes.
Lien Andries +11 more
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Archives of Neurology, 1999 A few brief years ago, damage to the central nervous system was generally perceived to be irreparable, and loss of neurons was largely viewed as an irreversible process. However, major advances in the study of neural progenitor cells have altered these perceptions, and rational approaches to the repair of the damaged nervous system using transplanted ...
M F, Mehler, J A, Kessler
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Biology of the adult enteric neural stem cell [PDF]
Developmental Dynamics, 2006 AbstractAn increasing body of evidence has accumulated in recent years supporting the existence of neural stem cells in the adult gut. There are at least three groups that have obtained them using different methodologies and have described them in vitro.
Sandino, Estrada-Mondaca +2 more
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Reliable interpretability of biology-inspired deep neural networks
npj Systems Biology and Applications, 2023 Abstract Deep neural networks display impressive performance but suffer from limited interpretability. Biology-inspired deep learning, where the architecture of the computational graph is based on biological knowledge, enables unique interpretability where real-world concepts are encoded in hidden nodes, which can be ranked by ...
Wolfgang Esser-Skala, Nikolaus Fortelny
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Insights into neural stem cell biology from flies [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2007 Drosophilaneuroblasts are similar to mammalian neural stem cells in their ability to self-renew and to produce many different types of neurons and glial cells. In the past two decades, great advances have been made in understanding the molecular mechanisms underlying embryonic neuroblast formation, the establishment of cell polarity and the temporal ...
Boris, Egger +2 more
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