Results 41 to 50 of about 335,509 (265)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Dissecting the connection between volatile organic compounds and cardiovascular disease: immune cell-mediated mechanism

Ecotoxicology and Environmental Safety
Background: Volatile organic compounds (VOCs) are increasingly recognized as environmental pollutants with detrimental effects on human health. However, their specific effect on cardiovascular disease remains insufficiently explored.
Qi Cao, Jiajing Liu, Daiyao Lu, Junhuai Song, Qiming Yu, Jinkun Wen, Bin Zheng   +6 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Mesenchymal stem cells undergoing apoptosis recover cyclophosphamide-induced cleft palate through modulation of NLR signaling mediated pyroptosis

Stem Cell Research & Therapy
Background Cleft palate is a common developmental disorder in craniofacial region, which cause the severe postnatal oral dysfunction. Mesenchymal stem cell (MSC) therapy has been revealed as a promising therapeutic approach in fetal developmental defects.
Xi Zheng, Yu Fu, Hongbin Lu, Lizhen Lan, Xiaohan Geng, Peiyuan Zhang, Bingdong Sui, Xuefeng Hu   +7 more
doaj   +1 more source

The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons

Communications Biology, 2021
Yasunori Mori et al. find that a subset of neurotransmitter-bearing synaptic vesicles are marked for release by the endosomal Q-SNARE protein Stx7. They show that Stx7 function is necessary for the rapid replenishment of synaptic vesicles that is needed ...
Yasunori Mori, Koh-ichiro Takenaka, Yugo Fukazawa, Shigeo Takamori   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Elucidating the Relationship Between Diabetes Mellitus and Parkinson’s Disease Using 18F-FP-(+)-DTBZ, a Positron-Emission Tomography Probe for Vesicular Monoamine Transporter 2

Frontiers in Neuroscience, 2020
Diabetes mellitus (DM) and Parkinson’s disease (PD) have been and will continue to be two common chronic diseases globally that are difficult to diagnose during the prodromal phase.
Yanyan Kong, Haicong Zhou, Hu Feng, Junyi Zhuang, Tieqiao Wen, Chencheng Zhang, Bomin Sun, Jiao Wang, Yihui Guan   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The Biology of Linguistic Expression Impacts Neural Correlates for Spatial Language [PDF]

Journal of Cognitive Neuroscience, 2013
AbstractBiological differences between signed and spoken languages may be most evident in the expression of spatial information. PET was used to investigate the neural substrates supporting the production of spatial language in American Sign Language as expressed by classifier constructions, in which handshape indicates object type and the location ...
Karen Emmorey, Stephen McCullough, Sonya H. Mehta, Laura L. Boles Ponto, Thomas J. Grabowski   +4 more
openaire   +3 more sources

Comprehensive transcript-level analysis reveals transcriptional reprogramming during the progression of Alzheimer’s disease

Frontiers in Aging Neuroscience, 2023
BackgroundAlzheimer’s disease (AD) is a common neurodegenerative disorder that has a multi-step disease progression. Differences between moderate and advanced stages of AD have not yet been fully characterized.Materials and methodsHerein, we performed a ...
Hao Wu, Jiao Wang, Xiaoyuan Hu, Cheng Zhuang, Jianxin Zhou, Peiru Wu, Shengli Li, Robert Chunhua Zhao, Robert Chunhua Zhao   +8 more
doaj   +1 more source