Results 41 to 50 of about 337,560 (313)

Mendelian randomization studies of diagnostic value of standard biochemistry serum enzymes portfolio in cardiovascular diseases

open access: yesArchives of Medical Science
Introduction Material and methods Results ...
Jiajing Liu   +4 more
doaj   +1 more source

Progenitor Cell Biology [PDF]

open access: yesArchives of Neurology, 1999
A few brief years ago, damage to the central nervous system was generally perceived to be irreparable, and loss of neurons was largely viewed as an irreversible process. However, major advances in the study of neural progenitor cells have altered these perceptions, and rational approaches to the repair of the damaged nervous system using transplanted ...
M F, Mehler, J A, Kessler
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Mechanisms and Implications of Mitochondrial Autophagy in Stroke

open access: yesNeuropharmacology and Therapy
Stroke is an acute cerebrovascular disease that is caused by disruptions in the cerebral blood supply and leads to brain tissue damage. Its pathological mechanisms remain to be fully elucidated. Stroke has high incidence, disability, and mortality rates,
Rabia Sultan   +7 more
doaj   +1 more source

Nanoparticles used in dentistry: A review

open access: yesJournal of Oral Biology and Craniofacial Research, 2018
Nanotechnology is widely used in our day to day life including its use in medicine. Using nanotechnology, it is easy to analyze and manipulate atoms, chemical bonds and molecules present between various compounds.
Subhashree Priyadarsini   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Virtual living organism: A rapid prototyping tool to emulate biology [PDF]

open access: yes, 2011
Rapid prototyping tools exist in many fields of science and engineering, but are rare in biology especially not general tools that can handle the diversity and complexity of the many spatial and temporal scales in nature.
Bándi, Gergely
core  

KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells

open access: yesCommunications Biology, 2022
KLF4-induced phenotypic switching of vascular smooth muscle cells occurs in atherosclerosis. Now, KLF4 is shown to induce a glycolytic shift involving upregulation of PFKFB3 expression through circular RNA CTDP1 and eukaryotic elongation factor eEF1A2.
Xinhua Zhang   +12 more
doaj   +1 more source

Comprehensive transcript-level analysis reveals transcriptional reprogramming during the progression of Alzheimer’s disease

open access: yesFrontiers in Aging Neuroscience, 2023
BackgroundAlzheimer’s disease (AD) is a common neurodegenerative disorder that has a multi-step disease progression. Differences between moderate and advanced stages of AD have not yet been fully characterized.Materials and methodsHerein, we performed a ...
Hao Wu   +8 more
doaj   +1 more source

Systems Biology Approach to Imaging of Neural Stem Cells [PDF]

open access: yes, 2010
Over the past decade, the advances in human brain magnetic resonance imaging (MRI) have significantly improved our ability to gain insightful information about the structure and function of the brain. One of the MRI imaging modalities that still awaits more comprehensive data mining is magnetic resonance spectroscopy (MRS).
Li Hua, Ma   +3 more
openaire   +2 more sources

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