Results 61 to 70 of about 777,664 (296)
Stem Cell Research & TherapyBackground Cleft palate is a common developmental disorder in craniofacial region, which cause the severe postnatal oral dysfunction. Mesenchymal stem cell (MSC) therapy has been revealed as a promising therapeutic approach in fetal developmental defects.
Xi Zheng +7 more
doaj +1 more source
The killifish visual system as an in vivo model to study brain aging and rejuvenation
npj Aging and Mechanisms of Disease, 2021 Worldwide, people are getting older, and this prolonged lifespan unfortunately also results in an increased prevalence of age-related neurodegenerative diseases, contributing to a diminished life quality of elderly.
Sophie Vanhunsel +8 more
doaj +1 more source
Modeling spinal locomotor circuits for movements in developing zebrafish
eLife, 2021 Many spinal circuits dedicated to locomotor control have been identified in the developing zebrafish. How these circuits operate together to generate the various swimming movements during development remains to be clarified. In this study, we iteratively
Yann Roussel +4 more
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The dawn of mathematical biology [PDF]
, 2015 In this paper I describe the early development of the so-called mathematical biophysics, as conceived by Nicolas Rashevsky back in the 1920's, as well as his latter idealization of a "relational biology". I also underline that the creation of the journal
Hoffmann, Daniel Sander
core +2 more sources
A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
, 2012 We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid.
Graben, Peter beim, Rodrigues, Serafim
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Redundant neural vision systems: competing for collision recognition roles [PDF]
, 2013 Ability to detect collisions is vital for future robots that interact with humans in complex visual environments. Lobula giant movement detectors (LGMD) and directional selective neurons (DSNs) are two types of identified neurons found in the visual ...
Rind, F. Claire, Yue, Shigang
core +1 more source
The epitranscriptome in stem cell biology and neural development
Neurobiology of Disease, 2020 The blossoming field of epitranscriptomics has recently garnered attention across many fields by findings that chemical modifications on RNA have immense biological consequences. Methylation of nucleotides in RNA, including N6-methyladenosine (m6A), 2-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), 5-methylcytosine (m5C), and isomerization of ...
Caroline Vissers +3 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2021 Alzheimer’s disease (AD), a serious neurodegenerative disease, is pathologically characterized by synaptic loss and dysfunction. Synaptic vesicle protein 2A (SV2A) is an indispensable vesicular protein specifically expressed in synapses and can be used ...
Yanyan Kong +15 more
doaj +1 more source