Results 61 to 70 of about 3,276,277 (298)

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Mechanisms and Implications of Mitochondrial Autophagy in Stroke

Neuropharmacology and Therapy
Stroke is an acute cerebrovascular disease that is caused by disruptions in the cerebral blood supply and leads to brain tissue damage. Its pathological mechanisms remain to be fully elucidated. Stroke has high incidence, disability, and mortality rates,
Rabia Sultan, Qing Zou, Yiyang Cao, Huanle Hong, Ruiqi Sun, Cheng Zhuang, Robert Chunhua Zhao, Jiao Wang   +7 more
doaj   +1 more source

KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells

Communications Biology, 2022
KLF4-induced phenotypic switching of vascular smooth muscle cells occurs in atherosclerosis. Now, KLF4 is shown to induce a glycolytic shift involving upregulation of PFKFB3 expression through circular RNA CTDP1 and eukaryotic elongation factor eEF1A2.
Xinhua Zhang, Bin Zheng, Lingdan Zhao, Jiayi Shen, Zhan Yang, Yu Zhang, Ruirui Fan, Manli Zhang, Dong Ma, Lemin Zheng, Mingming Zhao, Huirong Liu, Jinkun Wen   +12 more
doaj   +1 more source

Systems Biology Approach to Imaging of Neural Stem Cells [PDF]

, 2010
Over the past decade, the advances in human brain magnetic resonance imaging (MRI) have significantly improved our ability to gain insightful information about the structure and function of the brain. One of the MRI imaging modalities that still awaits more comprehensive data mining is magnetic resonance spectroscopy (MRS).
Li Hua, Ma, Yao, Li, Petar M, Djurić, Mirjana, Maletić-Savatić   +3 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons

Communications Biology, 2021
Yasunori Mori et al. find that a subset of neurotransmitter-bearing synaptic vesicles are marked for release by the endosomal Q-SNARE protein Stx7. They show that Stx7 function is necessary for the rapid replenishment of synaptic vesicles that is needed ...
Yasunori Mori, Koh-ichiro Takenaka, Yugo Fukazawa, Shigeo Takamori   +3 more
doaj   +1 more source

The genetics and molecular biology of neural tumors [PDF]

British Journal of Cancer, 2010
The rapid development of molecular biology techniques in the last three decades has seen a powerful shift from classical cytogenetics to chip technologies and deep sequencing of whole tumour genomes. Today, several relatively low-cost technologies enable us to study whole tumour genomes and gather information about a tumour's genomic, transcripteomic ...
openaire   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mesenchymal stem cells undergoing apoptosis recover cyclophosphamide-induced cleft palate through modulation of NLR signaling mediated pyroptosis

Stem Cell Research & Therapy
Background Cleft palate is a common developmental disorder in craniofacial region, which cause the severe postnatal oral dysfunction. Mesenchymal stem cell (MSC) therapy has been revealed as a promising therapeutic approach in fetal developmental defects.
Xi Zheng, Yu Fu, Hongbin Lu, Lizhen Lan, Xiaohan Geng, Peiyuan Zhang, Bingdong Sui, Xuefeng Hu   +7 more
doaj   +1 more source

Dissecting the connection between volatile organic compounds and cardiovascular disease: immune cell-mediated mechanism

Ecotoxicology and Environmental Safety
Background: Volatile organic compounds (VOCs) are increasingly recognized as environmental pollutants with detrimental effects on human health. However, their specific effect on cardiovascular disease remains insufficiently explored.
Qi Cao, Jiajing Liu, Daiyao Lu, Junhuai Song, Qiming Yu, Jinkun Wen, Bin Zheng   +6 more
doaj   +1 more source