Results 81 to 90 of about 337,560 (313)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Bird brains and songs : Neural mechanisms of auditory memory and perception in zebra finches
, 2009 Songbirds, such as zebra finches, learn their songs from a ‘tutor’ (usually the father), early in life. There are strong parallels between the behavioural, cognitive and neural processes that underlie vocal learning in humans and songbirds. In both cases
Gobes, S.M.H. +3 more
core
Show a Threshold Effect in Response to Radiation
Dose-Response, 2014 We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses.
Michael Antosh +5 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2017 Aging progression is a process that an individual encounters as they become older, and usually results from a series of normal physiological changes over time.
Jiao Wang +10 more
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Cell Transplantation, 2016 Stem cell transplantation has enormous potential for the treatment of neurodegenerative disorders like Parkinson's disease (PD). Mesenchymal stem cells (MSCs) have attracted much attention because they can secrete a wide variety of cellular factors that ...
Yuan Yao +3 more
doaj +1 more source
Neural plasticity and adult neurogenesis: the deep biology perspective
Neural Regeneration Research, 2019 The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of ...
Colangelo AM +4 more
openaire +5 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation
Communications BiologyAberrant autophagy in vascular smooth muscle cells (VSMCs) is associated with the progression of vascular remodeling diseases caused by neointimal hyperplasia.
Shi-Qing Mu +16 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source