Results 101 to 110 of about 337,560 (313)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Metabolic, Replication and Genomic Category of Systems in Biology, Bioinformatics and Medicine

, 2012
Metabolic-repair models, or (M,R)-systems were introduced in Relational Biology by Robert Rosen. Subsequently, Rosen represented such (M,R)-systems (or simply MRs)in terms of categories of sets, deliberately selected without any structure other than the ...
I. C. Baianu
core  

Signalling events controlling early cell fate decisions in a human embryonal carcinoma cell line, with relation to neural versus non-neural transitions m human ectoderm development [PDF]

, 2007
In this study the human embryonal carcinoma cell line TERA2.cl.spl2 (TERA2.spl2) was utilised as an in vitro model in which to study mechanisms governing neural versus non- neural transitions in the human ectoderm.
Horrocks, Grace Mary
core  

Induction of human stem cells into ameloblasts by reaggregation strategy

Stem Cell Research & Therapy
Background Human epithelium-derived stem cells and induced pluripotent stem cells (hiPSCs) possess the capability to support tooth formation and differentiate into functional enamel-secreting ameloblasts, making them promising epithelial-component ...
Chensheng Lin, Shiyu Liu, Minjun Huang, Yanding Zhang, Xuefeng Hu   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Neural Circuit Mechanisms Underlying Cognition in Rats

, 2019
Presented on March 11, 2019 at 11:!5 a.m. in the Krone Engineered Biosystems Building, Room 100.Carlos D. Brody is an American neuroscientist currently the Wilbur H.
Brody, Carlos
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Defining properties of neural crest-derived progenitor cells from the apex of human developing tooth [PDF]

, 2008
The connective tissue of the human tooth arises from cells that are derived from the cranial neural crest and, thus, are termed as "ectomesenchymal cells." Here, cells being located in a pad-like tissue adjacent to the apex of the developing tooth, which
Götz, Werner, Schönebeck, Bodo, Degistirici, Ozer, Siemonsmeier, Jürgen, Martin, Ivan, Jaquiery, Claude, Thie, Michael   +6 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Enteric neurospheres are not specific to neural crest cultures: implications for neural stem cell therapies. [PDF]

, 2015
Enteric neural stem cells provide hope of curative treatment for enteric neuropathies. Current protocols for their harvesting from humans focus on the generation of 'neurospheres' from cultures of dissociated gut tissue.
Ellen Binder, Kronfli Rania, Binder Ellen, Julie Cooper (709302), Cooper Julie, Thapar Nikhil, Conor McCann, Cananzi Mara, Cananzi, M, Jean-Marie Delalande (709304), Dipa Natarajan (709301), Conor McCann (709305), Cananzi, M. (Mara), Dipa Natarajan, Delalande Jean-Marie, Binder, E, McCann, C.J. (Conor), Nikhil Thapar, Nikhil Thapar (709307), Mara Cananzi (255527), Burns Alan J., Cooper, J.E. (Julie E.), Thapar, N. (Nikhil), Alan J Burns, Delalande, JM, Natarajan, D, Jean-Marie Delalande, Burns, A.J. (Alan), McCann, C, Rania Kronfli (709303), Delalande, J.-M. (Jean-Marie), McCann Conor, Mara Cananzi, Delalande, J-M, Natarajan, D. (Dipa), Julie Cooper, Burns, AJ, Thapar, N, Binder, E. (Ellen), Ellen Binder (709300), Alan J. Burns (709306), Cooper, J, Natarajan Dipa, Kronfli, R, Kronfli, R. (Rania), Rania Kronfli   +45 more
core   +1 more source

VSX1 EXPRESSION INITIALLY DESCRIBED IN THE V2 SPINAL INTERNEURON PRECURSOR CELLS IS ALSO PRESENT IN THE ADULT SPINAL CORD AND MAINTAINED AFTER A TRAUMATIC INJURY

IBRO Neuroscience Reports, 2023
Ana Dominguez-Bajo, Andrea Angla, Guillaume Van Lint, Stéphanie Debrulle, Frédéric Clotman   +4 more
doaj   +1 more source