Results 51 to 60 of about 337,560 (313)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Ecotoxicology and Environmental SafetyBackground: Volatile organic compounds (VOCs) are increasingly recognized as environmental pollutants with detrimental effects on human health. However, their specific effect on cardiovascular disease remains insufficiently explored.
Qi Cao +6 more
doaj +1 more source
Communications Biology, 2021 Yasunori Mori et al. find that a subset of neurotransmitter-bearing synaptic vesicles are marked for release by the endosomal Q-SNARE protein Stx7. They show that Stx7 function is necessary for the rapid replenishment of synaptic vesicles that is needed ...
Yasunori Mori +3 more
doaj +1 more source
The genetics and molecular biology of neural tumors [PDF]
British Journal of Cancer, 2010 The rapid development of molecular biology techniques in the last three decades has seen a powerful shift from classical cytogenetics to chip technologies and deep sequencing of whole tumour genomes. Today, several relatively low-cost technologies enable us to study whole tumour genomes and gather information about a tumour's genomic, transcripteomic ...
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells [PDF]
, 2014 Neurogenesis is initiated by a set of basic Helix-Loop-Helix (bHLH) transcription factors that specify neural progenitors and allow them to generate neurons in multiple rounds of asymmetric cell division.
Heinrich Reichert +15 more
core +1 more source
Stem Cell Research & TherapyBackground Cleft palate is a common developmental disorder in craniofacial region, which cause the severe postnatal oral dysfunction. Mesenchymal stem cell (MSC) therapy has been revealed as a promising therapeutic approach in fetal developmental defects.
Xi Zheng +7 more
doaj +1 more source
The Biology of Linguistic Expression Impacts Neural Correlates for Spatial Language [PDF]
Journal of Cognitive Neuroscience, 2013 AbstractBiological differences between signed and spoken languages may be most evident in the expression of spatial information. PET was used to investigate the neural substrates supporting the production of spatial language in American Sign Language as expressed by classifier constructions, in which handshape indicates object type and the location ...
Karen Emmorey +4 more
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Complementarity of spike- and rate-based dynamics of neural systems
, 2012 Relationships between spiking-neuron and rate-based approaches to the dynamics of neural assemblies are explored by analyzing a model system that can be treated by both methods, with the rate-based method further averaged over multiple neurons to give a ...
P A Robinson +11 more
core +1 more source