Results 21 to 30 of about 335,509 (265)
Journal of Advanced Research, 2022 Introduction: Hypoxia-inducible factor (HIF)1α has been shown to be activated and induces a glycolytic shift under hypoxic condition, however, little attention was paid to the role of HIF1α-actuated fructolysis in hypoxia-induced heart injury. Objectives:
Yu Zhang +8 more
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Advanced Science, 2023 Epidemiological studies show an association between inflammatory bowel disease (IBD) and increased risk of thrombosis. However, how IBD influences thrombosis remains unknown. The current study shows that formation of neutrophil extracellular traps (NETs)
Long Zhang +10 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom +15 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Editorial: “Unravelling neural stem cell biology: players and strategies”
Frontiers in Cell and Developmental Biology, 2023 The properties and behaviour of adult or somatic neural stem cells (NSCs) are governed by a complex network of intrinsic molecules and pathways along with a milieu of extrinsic signals hailed from the extremely controlled environment or niche in which they reside.
Ma Salomé Sirerol-Piquer +9 more
openaire +6 more sources
Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System
Mediators of Inflammation, 2017 Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited capacity of CNS regeneration.
Ilse Bollaerts +4 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Insights into neural stem cell biology from flies [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2007 Drosophila neuroblasts are similar to mammalian neural stem cells in their ability to self-renew and to produce many different types of neurons and glial cells. In the past two decades, great advances have been made in understanding the molecular mechanisms underlying embryonic neuroblast formation, the ...
Boris, Egger +2 more
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Molecular BiomedicineMitochondria play an essential role in regulating various physiological functions including bioenergetics, calcium homeostasis, redox signaling, and lipid metabolism and also are involved in the pathogenesis of cardiovascular diseases.
Zhiwang Zhang +9 more
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Archives of Medical ScienceIntroduction Material and methods Results ...
Jiajing Liu +4 more
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