Results 11 to 20 of about 337,560 (313)

Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
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Computational inference of neural information flow networks [PDF]

, 2006
This research was supported by a Packard Foundation grant and a US National Science Foundation (NSF) Waterman Award to EDJ, an NSF CAREER grant and an Alfred P.
Tom V. Smulders, Hartemink Alexander J, Hartemink, Alexander J, V. Anne Smith, Smith, Victoria Anne, Alexander J Hartemink, Yu Jing, Hartemink, Alex J, Erich D. Jarvis, Tom V Smulders, Smith V. Anne, Alexander J. Hartemink, Jing Yu, Smulders Tom V, Yu, Jing, Smulders, Tom V, V Anne Smith, Smith, V Anne, Erich D Jarvis, Jarvis, Erich D, Jarvis Erich D   +20 more
core   +1 more source

Insights into the Biology and Therapeutic Applications of Neural Stem Cells [PDF]

Stem Cells International, 2016
The cerebral cortex is essential for our higher cognitive functions and emotional reasoning. Arguably, this brain structure is the distinguishing feature of our species, and yet our remarkable cognitive capacity has seemingly come at a cost to the regenerative capacity of the human brain.
Harris, L., Zalucki, O., Piper, M., Heng, Julian   +3 more
openaire   +7 more sources

Dcf1 induces glioblastoma cells apoptosis by blocking autophagy

Cancer Medicine, 2022
Background Dcf1 has been demonstrated to play vital roles in many CNS diseases, it also has a destructive role on cell mitochondria in glioma cells and promotes the autophagy.
Guanghong Luo, Ruili Feng, Wengang Li, Yanlu Chen, Yangyang Sun, Junfeng Ma, Yanhong Duo, Tieqiao Wen   +7 more
doaj   +1 more source

Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene

Food Science and Human Wellness, 2023
Benzo[a]pyrene (B[a]P) is a food contaminant toxic for cardiovascular diseases. The nuclear translocation of Arylhydrocarbon receptor (AhR) plays an important role in B[a]P-induced oxidative stress and vascular diseases.
Rong Wang, Yun Huang, Xiaoruo Gan, Chenghao Fu, Yuemin Li, Ning Chen, Hao Xi, Huishan Guo, Wei Zhang, Yuhong Lü, Yan Zhang, Pin Lü   +11 more
doaj   +1 more source

Neural stem cells in Drosophila : molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formation [PDF]

, 2012
Neural stem cells in Drosophila are currently one of the best model systems for understanding stem cell biology during normal development and during abnormal development of stem cell-derived brain tumors.
Heinrich Reichert, Reichert, Heinrich, Saini, Nidhi, Nidhi Saini   +3 more
core   +1 more source

Multi-Modal Pain Intensity Assessment Based on Physiological Signals: A Deep Learning Perspective

Frontiers in Physiology, 2021
Traditional pain assessment approaches ranging from self-reporting methods, to observational scales, rely on the ability of an individual to accurately assess and successfully report observed or experienced pain episodes.
Patrick Thiam, Patrick Thiam, Heinke Hihn, Daniel A. Braun, Hans A. Kestler, Friedhelm Schwenker   +5 more
doaj   +1 more source

CRYAA and GJA8 promote visual development after whisker tactile deprivation

Heliyon, 2023
Deprivation of one sense can be followed by enhanced development of other senses via cross-modal plasticity mechanisms. To study the effect of whisker tactile deprivation on vision during the early stages of development, we clipped the bilateral whiskers
Shibo Zhang, Cuiping Liu, Qian Wang, Haicong Zhou, Hao Wu, Junyi Zhuang, Yiyang Cao, Hongwei Shi, Jingfa Zhang, Jiao Wang   +9 more
doaj   +1 more source

The epitranscriptome in stem cell biology and neural development

Neurobiology of Disease, 2020
The blossoming field of epitranscriptomics has recently garnered attention across many fields by findings that chemical modifications on RNA have immense biological consequences. Methylation of nucleotides in RNA, including N6-methyladenosine (m6A), 2-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), 5-methylcytosine (m5C), and isomerization of ...
Caroline Vissers, Aniketa Sinha, Guo-li Ming, Hongjun Song   +3 more
openaire   +3 more sources

Drosophila melanogaster as a model to understand the mechanisms of infection mediated neuroinflammation in neurodegenerative diseases

Journal of Integrative Neuroscience, 2022
The innate immune system primarily gets triggered by microbe infiltration, injury, stress, aging, and brain disorders. The hyperactivation of the innate immune system and neuroinflammatory reactions contributes to chronic age-related neurodegeneration ...
Nibedita Nayak, Monalisa Mishra
doaj   +1 more source