Results 131 to 140 of about 288,351 (166)

Raf-1 activates MAP kinase-kinase

Nature, 1992
The normal cellular homologue of the acutely transforming oncogene v-raf is c-raf-1, which encodes a serine/threonine protein kinase that is activated by many extracellular stimuli. The physiological substrates of the protein c-Raf-1 are unknown.
J M, Kyriakis, H, App, X F, Zhang, P, Banerjee, D L, Brautigan, U R, Rapp, J, Avruch   +6 more
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Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Nature Structural & Molecular Biology, 2004
MEK1 and MEK2 are closely related, dual-specificity tyrosine/threonine protein kinases found in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathway. Approximately 30% of all human cancers have a constitutively activated MAPK pathway, and constitutive activation of MEK1 results in cellular transformation.
Jeffrey F, Ohren, Huifen, Chen, Alexander, Pavlovsky, Christopher, Whitehead, Erli, Zhang, Peter, Kuffa, Chunhong, Yan, Patrick, McConnell, Cindy, Spessard, Craig, Banotai, W Thomas, Mueller, Amy, Delaney, Charles, Omer, Judith, Sebolt-Leopold, David T, Dudley, Iris K, Leung, Cathlin, Flamme, Joseph, Warmus, Michael, Kaufman, Stephen, Barrett, Haile, Tecle, Charles A, Hasemann   +21 more
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Phosphorylation and activation of smooth muscle myosin light chain kinase by MAP kinase and cyclin-dependent kinase-1

Biochemistry and Cell Biology, 1996
Smooth muscle myosin light chain kinase (MLCK) features several consensus sites of phosphorylation by proline-directed protein serine/threonine kinases. The phosphorylation of MLCK by two proline-directed kinases isolated from sea star oocytes, i.e., p44mpk (Mpk, a mitogen-activated protein kinase homologue) and cyclin-dependent kinase-1 (CDK1, also ...
D L, Morrison, J S, Sanghera, J, Stewart, C, Sutherland, M P, Walsh, S L, Pelech   +5 more
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MAP kinase/ERK kinase 1 (MEK1) phosphorylates regulator of calcineurin 1 (RCAN1) to regulate neuronal differentiation

Journal of Cellular Physiology, 2021
AbstractRegulator of calcineurin 1 (RCAN1) is located close to the Down syndrome critical region (DSCR) on human chromosome 21 and is related to the Down syndrome (DS) phenotype. To identify a novel binding partner of RCAN1, we performed yeast two‐hybrid screening and identified mitogen‐activated protein (MAP) kinase/extracellular signal‐regulated ...
Seon Sook Kim, Eun Hye Lee, Jin Hak Shin, Su Ryeon Seo   +3 more
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MAP kinase kinase 1 (MKK1) is essential for transmission of Trypanosoma brucei by Glossina morsitans

Molecular and Biochemical Parasitology, 2012
MAP kinase kinase 1 (MKK1) is encoded by a single copy gene in Trypanosoma brucei. It has been shown recently that MKK1 is not essential for bloodstream forms [14]. To investigate the requirement for MKK1 in other life-cycle stages we generated null mutants in procyclic forms of a fly-transmissible strain.
Morand, S., Kunz Renggli, C., Roditi, I., Vassella, E.   +3 more
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Epitope Mapping of DhMab-1: An Antidiacylglycerol Kinase Monoclonal Antibody

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2020
Diacylglycerol kinase (DGK) η is classified as a type II DGK and catalyzes diacylglycerol phosphorylation to produce phosphatidic acid. DGKη has been reported to be highly expressed in the hippocampus and cerebellum. Although a DGKη-specific monoclonal antibody (mAb) is necessary to reveal the association between the expression of ...
Masato, Sano, Mika K, Kaneko, Yukinari, Kato   +2 more
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Interleukin-1 activates a novel p54 MAP Kinase Kinase in rabbit liver

1997
The major inflammatory cytokine interleukin-1 (IL-1) exerts pleiotropic effects during acute or chronic inflammatory disease. On a cellular level it often increases expression of genes for many proteins involved in initiating or maintaining an inflammatory process, like cytokines (IL-2, IL-6, IL-8, G-CSF, GM-CSF), adhesion molecules (ICAM-1, SLAM-1 ...
Michael Kracht, Andrew Finch, Jeremy Saklatvala   +2 more
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40 Sphingosine 1-phosphate activation of MAP kinase — involvement of PI 3-kinase and protein kinase C

Biochemical Society Transactions, 1997
In addition to its proposed intracellular role 111, sphingosine 1phosphate (SphP) may belong to a new class of extracellular lysophospholipid mediators which bind to specific cell surface receptors. SphP has been reported to induce neurite retraction 121, open K' channels [3,4], evoke Ca2' entry [3] and to stimulate phospholipase D and DNA binding of ...
ANN-MARIE CONWAY, NIGEL J. PYNE, SUSAN PYNE   +2 more
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MAP Kinase Activation by Flow in Endothelial Cells

Circulation Research, 1996
Local alterations in the hemodynamic environment regulate endothelial cell function, but the signal-transduction mechanisms involved in this process remain unclear. We previously demonstrated that mitogen-activated protein (MAP) kinase is rapidly stimulated by flow in bovine aortic endothelial cells.
T, Ishida, T E, Peterson, N L, Kovach, B C, Berk   +3 more
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Map location of the thymidine kinase gene of bovine herpesvirus 1

Journal of Virology, 1987
Bovine herpesvirus 1 has been reported to contain a thymidine kinase (tk) gene which is nonessential for virus replication. We have isolated a thymidine kinase-negative mutant of the virus and localized the mutation by marker rescue experiments to a 1.1-kilobase BglII-SalI fragment which maps at 0.47 to 0.48 on the bovine herpesvirus 1 genomic map.
L J, Bello, J C, Whitbeck, W C, Lawrence
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