Results 1 to 10 of about 1,035,719 (353)

The role of atypical MAP kinase 4 in the host interaction with Cryptosporidium parvum [PDF]

Scientific Reports, 2022
AbstractCryptosporidium parvum is an apicomplexan parasite that causes severe zoonotic diarrhea in humans and calves. Since there are no effective treatments or vaccines for infants or immunocompromised patients, it is important to understand the molecular mechanisms of the parasite–host interaction for novel drug discovery.
Nina Watanabe, Hironori Bando, Fumi Murakoshi, Riku Sakurai, Mohammad Hazzaz Bin Kabir, Yasuhiro Fukuda, Kentaro Kato   +6 more
doaj   +4 more sources

Docosahexaenoic Acid Inhibits UVB-Induced Activation of NF-κB and Expression of COX-2 and NOX-4 in HR-1 Hairless Mouse Skin by Blocking MSK1 Signaling [PDF]

PLoS ONE, 2011
Exposure to ultraviolet-B (UVB) radiation induces inflammation and photocarcinogenesis in mammalian skin. Docosahexaenoic acid (DHA), a representative ω-3 polyunsaturated fatty acid, has been reported to possess anti-inflammatory and chemopreventive ...
A Manea, A Manea, A Mullen, A Murakami, AL Groeger, AL Kim, AP Pentland, Bharat B. Aggarwal, CE McCoy, CF Lee, D Richard, DA Lewis, DH Jho, E Kefaloyianni, EJ Chang, F Jiang, FR de Gruijl, G Kaur, GM Halliday, HF Tiano, HS Park, HW Lo, Hye-Kyung Na, I Cucoranu, I Diebold, JK Kim, JK Kundu, JK Kundu, Joydeb Kumar Kundu, Jun-Wan Shin, K Muller-Decker, K Otkjaer, K Wingler, KA Graham, KP An, KS Chun, KT Moe, L Reber, L Vermeulen, M Karin, M Sedeek, M Yamaura, MA Bachelor, Md. Mostafizur Rahman, N Tobar, R Wang, S Park, S Serini, SD Sharma, SE Dickinson, SM Beak, T Djordjevic, T Machida, T Shono, TM Wang, V Vila-del Sol, W Chamulitrat, WM Nauseef, WS An, Y Yan, Y Zhao, Y-J Surh, Young-Joon Surh, YP Sun   +63 more
core   +25 more sources

Selective Regulation of MAP Kinase Signaling by an Endomembrane Phosphatidylinositol 4-Kinase [PDF]

Journal of Biological Chemistry, 2011
Multiple MAP kinase pathways share components yet initiate distinct biological processes. Signaling fidelity can be maintained by scaffold proteins and restriction of signaling complexes to discreet subcellular locations. For example, the yeast MAP kinase scaffold Ste5 binds to phospholipids produced at the plasma membrane and promotes selective MAP ...
Henrik G. Dohlman, Steven D. Cappell
  +8 more sources

Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance [PDF]

Cell, 2000
Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations.
Petersen, Morten, Brodersen, P., Naested, H., Andreasson, E., Lindhart, U., Johansen, Bo, Nielsen, Henrik B., Lacy, M., Austin, M.J., Parker, J.E., Sharma, S.B., Klessig, D.F., Martienssen, R., Mattsson, O., Jensen, A.B., Mundy, John Williams   +15 more
openaire   +7 more sources

Stt4 PI 4-Kinase Localizes to the Plasma Membrane and Functions in the Pkc1-Mediated MAP Kinase Cascade [PDF]

Developmental Cell, 2002
Production of the essential phospholipid PI4P at the Golgi by the Pik1 kinase is required for protein secretion, while a distinct pool of PI4P generated by the Stt4 kinase is critical for normal actin cytoskeleton organization. We identify a transmembrane protein that stabilizes Stt4 at the plasma membrane where it directs synthesis of PI4P, which is ...
Scott D. Emr, Anjon Audhya
openaire   +5 more sources

Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways [PDF]

Journal of Biological Chemistry, 2011
MAP kinase phosphatase 4 (DUSP9/MKP-4) plays an essential role during placental development and is one of a subfamily of three closely related cytoplasmic dual-specificity MAPK phosphatases, which includes the ERK-specific enzymes DUSP6/MKP-3 and DUSP7/MKP-X.
Dickinson, Robin J., Delavaine, Laurent, Cejudo-Marin, Rocio, Stewart, Graeme, Staples, Christopher J., Didmon, Mark P., Garcia Trinidad, Antonio, Alonso, Andres, Pulido, Rafael, Keyse, Stephen M.   +9 more
openaire   +7 more sources

Involvement of HSP90 in ischemic postconditioning-induced cardioprotection by inhibition of the complement system, JNK and inflammation [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose To investigate whether heat shock protein 90 (HSP90) is involved in complement regulation in ischemic postconditioning (IPC). Methods The left coronary artery of rats underwent 30 min of occlusion, followed by 120 min of reperfusion and ...
Dong-Xiao Wang, Zheng Huang, Qing-Jie Li, Guo-Qiang Zhong, Yan He, Wei-Qiang Huang, Xiao-Li Cao, Rong-Hui Tu, Jian-Jun Meng   +8 more
doaj   +1 more source

Trypanosoma brucei Lipophosphoglycan Activates Host Immune Responses via the TLR-mediated p38 MAP Kinase and NF-κB Pathways

Zoonoses, 2023
This study was aimed at investigating the immunoregulatory effects of trypanosomal lipophosphoglycan (LPG) anchored to trypanosome membranes, including the formation of neutrophil extracellular traps (NETs) and neutrophil cytokine release after parasite ...
Kai Zhang, Ning Jiang, Naiwen Zhang, Liying Yu, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen   +7 more
doaj   +1 more source

Epitope Mapping of the Anti-Diacylglycerol Kinase Monoclonal Antibody DhMab-4 for Immunohistochemical Analysis [PDF]

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2020
Diacylglycerol kinase (DGK) plays a pivotal role in intracellular signaling pathways in mammals. Activated G protein-coupled receptor activates phospholipase C (PLC) through heterotrimeric G protein, following which PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into diacylglycerol (DG) and inositol 1,4,5-trisphosphate (IP3). DGK catalyzes
Yukinari Kato, Junko Takei, Masato Sano, Yusuke Sayama, Teizo Asano, Mika K. Kaneko   +5 more
openaire   +3 more sources

An Inverse Agonist of Estrogen-Related Receptor Gamma, GSK5182, Enhances Na⁺/I⁻ Symporter Function in Radioiodine-Refractory Papillary Thyroid Cancer Cells

Cells, 2023
Previously, we reported that an inverse agonist of estrogen-related receptor gamma (ERRγ), GSK5182, enhances sodium iodide (Na+/I−) symporter (NIS) function through mitogen-activated protein (MAP) kinase signaling in anaplastic thyroid cancer cells. This
Thoudam Debraj Singh, Jae Eon Lee, Kwang Hee Son, Bo Ra Lee, Sang Kyoon Kim, Deepak Gulwani, Vijaya Sarangthem, Yong Hyun Jeon   +7 more
doaj   +1 more source