Results 101 to 110 of about 1,035,719 (353)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

A knowledge graph representation learning approach to predict novel kinase-substrate interactions [PDF]

arXiv, 2022
The human proteome contains a vast network of interacting kinases and substrates. Even though some kinases have proven to be immensely useful as therapeutic targets, a majority are still understudied. In this work, we present a novel knowledge graph representation learning approach to predict novel interaction partners for understudied kinases.
arxiv  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Erythropoietin‐activated ERK/MAP kinase enhances GATA‐4 acetylation via phosphorylation of serine 261 of GATA‐4

Journal of Cellular Physiology, 2012
AbstractGATA‐4, a zinc finger transcription factor, plays a critical role in heart development. Previous studies have shown that p300‐targeted GATA‐4 acetylation increases GATA‐4 stability and transcriptional activity, which then stimulates hypertrophy of cardiomyocyte.
Jae Kwang Shim, Young Lan Kwak, Hyun-Mo Ryoo, Ji Hae Jun   +3 more
openaire   +3 more sources

Ebola virus VP35 induces high-level production of recombinant TPL-2–ABIN-2–NF-κB1 p105 complex in co-transfected HEK-293 cells [PDF]

, 2013
Activation of PKR (double-stranded-RNA-dependent protein kinase) by DNA plasmids decreases translation, and limits the amount of recombinant protein produced by transiently transfected HEK (human embryonic kidney)-293 cells.
Apostolaki, Baldi, Beinke, Beinke, Beinke, Beinke, Beinke, Belich, Bouwmeester, Ciechanover, Cohen, Coope, Costa, Dauber, Dumitru, Durocher, Elke MÜHLBERGER, Feng, Gantke, Geisse, George, Gray, Jia, Jia, Julia Janzen, Kabouridis, Kaufman, Lang, Liu, Nicholas A. Morrice, Papoutsopoulou, Pomerantz, Robinson, Roget, Sabrina Boussouf, Salmeron, Salmeron, Savinova, Schlaeger, Schumann, Steven Howell, Steven C. Ley, Thorsten Gantke, Waterfield, Waterfield, Wu, Yang, Zhao   +47 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Tauroursodeoxycholate Protects Rat Hepatocytes from Bile Acid-Induced Apoptosis via β1-Integrin- and Protein Kinase A-Dependent Mechanisms

Cellular Physiology and Biochemistry, 2015
Background/Aims: Ursodeoxycholic acid, which in vivo is rapidly converted into its taurine conjugate, is frequently used for the treatment of cholestatic liver disease.
Annika Sommerfeld, Roland Reinehr, Dieter Häussinger   +2 more
doaj   +1 more source

Pharmacological evidence for the stimulation of NADPH oxidase by P2X7 receptors in mouse submandibular glands [PDF]

, 2008
ATP in the 100 μM-1 mM concentration range provoked a calcium-independent increase of the oxidation of dichlorodihydrofluorescein (DCFH) to dichlorofluorescein (DCF) by mouse submandibular cells. 3′-O-(4-benzoyl)benzoyl adenosine 5′-triphosphate (BzATP),
A Donko, A Gillissen, A Gomes, A Orient, Aida Marino, AR Cross, AS Barroso, AV Amerongen, C Loetchutinat, CJ Vlahos, CM Cruz, CM Cruz, CP LeBel, DR Alessi, FR Sheppard, G Grynkiewicz, G Melino, Irantzu Gorrono Etxebarria, J Stolk, JD Lambeth, JE Bleasdale, Jean-Paul Dehaye, JP Dehaye, JP Dehaye, JT Turner, LC Anderson, LK Parvathenani, M Garcia-Marcos, M Geiszt, M Solle, MD Bradford, ME Brosky, MG Bonini, Michèle Seil, Mikel Garcia-Marcos, MT Quinn, R Ameziane-El-Hassani, RA North, S Pochet, SJ Ennion, Stéphanie Pochet, T Assari, Unai Fontanils, V Diatchuk, ZA Pfeiffer   +44 more
core   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Phosphoregulators:protein kinases and protein phosphatases of mouse [PDF]

, 2003
With the completion of the human and mouse genome sequences, the task now turns to identifying their encoded transcripts and assigning gene function. In this study, we have undertaken a computational approach to identify and classify all of the protein ...
, , Forrest, Alistair R.R., Grimmond, Sean, Huber, Thomas, Hume, David A., Ravasi, Timothy, Taylor, Darrin   +7 more
core   +2 more sources