Molecular Basis of Meiotic Maturation and Apoptosis of Oocytes, Sperm-Oocyte Interactions and Early Cleavage of Embryos in Mice, Role of Phosphatidylinositol 3-Kinase, Mos, Fas-Fas Ligand, Integrinα6 and MAP Kinase [PDF]
Cell Journal, 2005 The interaction between molecular biology and embryology made an extensive progress in the research on gametogenesis, fertilization and early embryogenesis in mice.
Yumi Hoshino +5 more
doaj
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
PLoS ONE, 2015 Scavenger receptor associated with endothelial cells I (SREC-I) was shown to be expressed in immune cells and to play a role in the endocytosis of peptides and antigen presentation.
Ayesha Murshid +4 more
doaj +1 more source
Smoking cessation affects human platelet activation induced by collagen
Tobacco Induced Diseases, 2019 Objective For patients undergoing surgery, quitting smoking prior to surgery is recommended, since smoking increases the risk of postoperative morbidity or mortality.
Mami Iida +4 more
doaj +1 more source
Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]
, 2011 p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Arthur, J. Simon C. +6 more
core +3 more sources
Journal of Experimental Medicine, 1998 Neisseria gonorrhoeae (Ngo), the etiologic agent of gonorrhea, induce a number of proinflammatory cytokines by contact to epithelial cells. Cytokine genes and a variety of other immune response genes are activated as a result of the regulatory function ...
M. Naumann +4 more
semanticscholar +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The
BMC Genomics, 2011 Background Hundreds of millions of people are infected with cryptosporidiosis annually, with immunocompromised individuals suffering debilitating symptoms and children in socioeconomically challenged regions at risk of repeated infections.
Artz Jennifer D +25 more
doaj +1 more source
RGC1/RGC2 deletions cause increased sensitivity to oxidative stress in Saccharomyces cerevisiae, which can be overcome by constitutive nuclear Yap1 expression [PDF]
, 2016 Oxidative stress mechanism in yeast presents an innovative pathway to understand in creating the next generation of antifungal drugs. Rgc1 and Rgc2 are paralogous proteins that regulate the Fps1 glycerol channel in hyperosmotic stress.
Tsai, Michelle
core +1 more source
An evolutionary perspective on the kinome of malaria parasites [PDF]
, 2012 Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin +6 more
core +1 more source