Results 121 to 130 of about 1,035,719 (353)

MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer’s Disease [PDF]

, 2021
Rashid Waseem, Saleha Anwar, Shama Khan, Anas Shamsi, Md. Imtaiyaz Hassan, Farah Anjum, Alaa Shafie, Asimul Islam, Dharmendra Kumar Yadav   +8 more
openalex   +1 more source

Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation [PDF]

, 2009
Transcription of the mast cell growth factor SCF (stem cell factor) is upregulated in inflammatory conditions, and this is dependent upon NF-kappaB, as well as the MAP kinases p38 and ERK activation.
Frossard, Nelly, Haegeman, Guy, Reber, Laurent, Vermeulen, Linda   +3 more
core   +3 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Quantitative and functional post-translational modification proteomics reveals that TREPH1 plays a role in plant thigmomorphogenesis [PDF]

, 2018
Plants can sense both intracellular and extracellular mechanical forces and can respond through morphological changes. The signaling components responsible for mechanotransduction of the touch response are largely unknown. Here, we performed a high-throughput SILIA (stable isotope labeling in Arabidopsis)-based quantitative phosphoproteomics analysis ...
arxiv   +1 more source

Follicle stimulating hormone signaling opposes the DRL-1/FLR-4 MAP Kinases to balance p38-mediated growth and lipid homeostasis inC. elegans [PDF]

, 2023
Sarah K. Torzone, Aaron Y. Park, Peter C. Breen, Natalie R. Cohen, Robert H. Dowen   +4 more
openalex   +1 more source

The role of the novel Th17 cytokine IL-26 in intestinal inflammation [PDF]

, 2008
Background and aims: Interleukin 26 (IL-26), a novel IL-10-like cytokine without a murine homologue, is expressed in T helper 1 (Th1) and Th17 cells. Currently, its function in human disease is completely unknown. The aim of this study was to analyse its
Auernhammer, Christoph J., Beigel, Florian, Brand, Stephan, Dambacher, J., Diepolder, Helmut M., Göke, Burkhard, Toni, Enrico N. de, Zitzmann, K.   +7 more
core   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

4-(Phenylselanyl)-2H-chromen-2-one-Loaded Nanocapsule Suspension—A Promising Breakthrough in Pain Management: Comprehensive Molecular Docking, Formulation Design, and Toxicological and Pharmacological Assessments in Mice

Pharmaceutics
Therapies for the treatment of pain and inflammation continue to pose a global challenge, emphasizing the significant impact of pain on patients’ quality of life.
Caren Aline Ramson da Fonseca, Vinicius Costa Prado, Jaini Janke Paltian, Jean Carlo Kazmierczak, Ricardo Frederico Schumacher, Marcel Henrique Marcondes Sari, Larissa Marafiga Cordeiro, Aline Franzen da Silva, Felix Alexandre Antunes Soares, Robson da Silva Oliboni, Cristiane Luchese, Letícia Cruz, Ethel Antunes Wilhelm   +12 more
doaj   +1 more source

Supplementary Tables 1-4 from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1 [PDF]

, 2023
Peter Birner, Andrea Beer, Ursula Vinatzer, Susanne Stary, Romana Höftberger, Nadine Nirtl, Fritz Wrba, Berthold Streubel, Sebastian F. Schoppmann   +8 more
openalex   +1 more source

Computation of a Theoretical Membrane Phase Diagram, and the Role of Phase in Lipid Raft-Mediated Protein Organization [PDF]

, 2018
Lipid phase heterogeneity in the plasma membrane is thought to be crucial for many aspects of cell signaling, but the physical basis of participating membrane domains such as "lipid rafts" remains controversial. Here we consider a lattice model yielding a phase diagram that includes several states proposed to be relevant for the cell membrane ...
arxiv   +1 more source