Need help? Recently identified phosphorylation targets of MAP kinase 4 aid plant immunity [PDF]
Plant Physiology, 2022 Jian Chen
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Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance [PDF]
Cell, 2000 Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations.
Morten Petersen +15 more
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MARK4 (MAP/microtubule affinity-regulating kinase 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Published in Atlas Database: May 2003 Online updated version: http://AtlasGeneticsOncology.org/Genes/MARK4ID419.html DOI: 10.4267/2042/37977 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
Alessandro Beghini
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Selective Regulation of MAP Kinase Signaling by an Endomembrane Phosphatidylinositol 4-Kinase [PDF]
Journal of Biological Chemistry, 2011 Multiple MAP kinase pathways share components yet initiate distinct biological processes. Signaling fidelity can be maintained by scaffold proteins and restriction of signaling complexes to discreet subcellular locations. For example, the yeast MAP kinase scaffold Ste5 binds to phospholipids produced at the plasma membrane and promotes selective MAP ...
Steven D. Cappell, Henrik Dohlman
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Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways [PDF]
Journal of Biological Chemistry, 2011 MAP kinase phosphatase 4 (DUSP9/MKP-4) plays an essential role during placental development and is one of a subfamily of three closely related cytoplasmic dual-specificity MAPK phosphatases, which includes the ERK-specific enzymes DUSP6/MKP-3 and DUSP7/MKP-X.
Robin J. Dickinson +9 more
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Pseudomonas syringae Effector Protein AvrB Perturbs Arabidopsis Hormone Signaling by Activating MAP Kinase 4 [PDF]
Cell Host & Microbe, 2010 Pathogenic microbes often modulate phytohormone physiology in the host to their advantage. We previously showed that the Pseudomonas syringae effector protein AvrB perturbs hormone signaling, as exemplified by upregulated expression of jasmonic acid response genes, and enhances plant susceptibility.
Haitao Cui +8 more
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Stt4 PI 4-Kinase Localizes to the Plasma Membrane and Functions in the Pkc1-Mediated MAP Kinase Cascade [PDF]
Developmental Cell, 2002 Production of the essential phospholipid PI4P at the Golgi by the Pik1 kinase is required for protein secretion, while a distinct pool of PI4P generated by the Stt4 kinase is critical for normal actin cytoskeleton organization. We identify a transmembrane protein that stabilizes Stt4 at the plasma membrane where it directs synthesis of PI4P, which is ...
Anjon Audhya, Scott D. Emr
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Resveratrol amplifies BMP-4-stimulated osteoprotegerin synthesis via p38 MAP kinase in osteoblasts
Molecular Medicine Reports, 2015 Resveratrol is a naturally occurring polyphenol that possesses health‑related properties, and is predominantly found in grapes and berries. Bone morphogenetic protein‑4 (BMP‑4) stimulates osteocalcin synthesis via p38 mitogen‑activated protein (MAP) kinase in osteoblast‑like MC3T3‑E1 cells.
Gen Kuroyanagi +6 more
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Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus [PDF]
The EMBO Journal, 2008 Plant and animal perception of microbes through pathogen surveillance proteins leads to MAP kinase signalling and the expression of defence genes. However, little is known about how plant MAP kinases regulate specific gene expression. We report that, in the absence of pathogens, Arabidopsis MAP kinase 4 (MPK4) exists in nuclear complexes with the ...
Jin‐Long Qiu +15 more
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Arabidopsis MAP kinase 4 regulates salicylic acid‐ and jasmonic acid/ethylene‐dependent responses via EDS1 and PAD4 [PDF]
The Plant Journal, 2006 SummaryArabidopsis MPK4 has been implicated in plant defense regulation because mpk4 knockout plants exhibit constitutive activation of salicylic acid (SA)‐dependent defenses, but fail to induce jasmonic acid (JA) defense marker genes in response to JA. We show here that mpk4 mutants are also defective in defense gene induction in response to ethylene (
Peter Brodersen +8 more
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