Results 11 to 20 of about 1,035,719 (353)

Regulation of MAP Kinase by the BMP-4/TAK1 Pathway in Xenopus Ectoderm

Developmental Biology, 2001
Bone morphogenetic protein-4 (BMP-4) induces epidermis and represses neural fate in Xenopus ectoderm. Our previous findings implicate p42 Erk MAP kinase (MAPK) in the response to neural induction. We have examined the effects of BMP-4 on MAPK activity in gastrula ectoderm.
Amy K. Sater, Mousumi Goswami, Aarti R. Uzgare   +2 more
openaire   +4 more sources

Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus [PDF]

The EMBO Journal, 2008
Plant and animal perception of microbes through pathogen surveillance proteins leads to MAP kinase signalling and the expression of defence genes. However, little is known about how plant MAP kinases regulate specific gene expression. We report that, in the absence of pathogens, Arabidopsis MAP kinase 4 (MPK4) exists in nuclear complexes with the ...
Qiu, Jinlong, Fiil, Berthe Katrine, Petersen, Klaus, Nielsen, Henrik Bjørn, Botanga, Christopher J, Thorgrimsen, Stephan Pascal, Palma, Kristoffer, Suarez Rodriguez, Maria Cristina, Sandbech-Clausen, Signe, Lichota, Jacek, Brodersen, Peter, Grasser, Klaus D, Mattsson, Ole, Glazebrook, Jane, Mundy, John, Petersen, Morten   +15 more
openaire   +6 more sources

Efficacy and gastrointestinal tolerability of ML3403, a selective inhibitor of p38 MAP kinase and CBS-3595, a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 in CFA-induced arthritis in rats [PDF]

Rheumatology, 2013
Mitogen-activated protein kinase (MAPK) p38 inhibitors have entered the clinical phase, although many of them have failed due to high toxicity and lack of efficacy. In the present study we compared the effects of the selective p38 inhibitor ML3403 and the dual p38-PDE4 inhibitor CBS-3595, on inflammatory and nociceptive parameters in a model of ...
Rodrigo B M Silva, Carlos Eduardo Leite, Maria M. Campos, Natália Fontana Nicoletti, Stefan Laufer, Diana A Koch, Fernanda Bueno Morrone, Alessandra H. Souza   +7 more
openaire   +4 more sources

MOM-4, a MAP Kinase Kinase Kinase–Related Protein, Activates WRM-1/LIT-1 Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans [PDF]

Molecular Cell, 1999
In C. elegans, a Wnt/WG-like signaling pathway down-regulates the TCF/LEF-related protein, POP-1, to specify posterior cell fates. Effectors of this signaling pathway include a beta-catenin homolog, WRM-1, and a conserved protein kinase, LIT-1. WRM-1 and LIT-1 form a kinase complex that can directly phosphorylate POP-1, but how signaling activates WRM ...
Roger J. Davis, Roger J. Davis, Martha C. Soto, Yanxia Bei, Christian E. Rocheleau, Rueyling Lin, Craig C. Mello, Tae Ho Shin, Jun Yasuda, Jun Yasuda   +9 more
openaire   +6 more sources

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

J Biol Chem 285,(2), 2010, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +4 more sources

MARK4 (MAP/microtubule affinity-regulating kinase 4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Published in Atlas Database: May 2003 Online updated version: http://AtlasGeneticsOncology.org/Genes/MARK4ID419.html DOI: 10.4267/2042/37977 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
Alessandro Beghini
openaire   +4 more sources

Pseudomonas syringae Effector Protein AvrB Perturbs Arabidopsis Hormone Signaling by Activating MAP Kinase 4 [PDF]

Cell Host & Microbe, 2010
Pathogenic microbes often modulate phytohormone physiology in the host to their advantage. We previously showed that the Pseudomonas syringae effector protein AvrB perturbs hormone signaling, as exemplified by upregulated expression of jasmonic acid response genes, and enhances plant susceptibility.
L. Xue, Haitao Cui, Jinfang Chu, Yujing Wang, Roger W. Innes, Jihong Fu, Jihong Fu, Jianmin Zhou, Cunyu Yan, Mingsheng Chen   +9 more
openaire   +5 more sources

Cytokine upregulation of proteinase‐activated‐receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinaseβin human endothelial cells [PDF]

British Journal of Pharmacology, 2007
Background and purpose:Up‐regulation of proteinase‐activated receptor‐2 (PAR2) is a factor in a number of disease states and we have therefore examined the signalling pathways involved in the expression of the receptor.Experimental approach:We investigated the effects of tumour necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), trypsin and the PAR2 ...
Ritchie, E., Saka, M., MacKenzie, C., Drummond, R.M., Wheeler-Jones, C., Kanke, T., Plevin, R.J.   +6 more
openaire   +5 more sources

Dual Specificity Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Plays a Potential Role in Insulin Resistance [PDF]

Journal of Biological Chemistry, 2003
Insulin is the key hormone that controls glucose homeostasis. Dysregulation of insulin function causes diabetes mellitus. Among the two major forms of diabetes, type 2 diabetes accounts for over 90% of the affected population. The incidence of type 2 diabetes is highly related to obesity.
Marlene Dembski, Daseng Yang, Rosana Kapeller, Olga Tayber, Haiyan Xu, Louis A. Tartaglia, Hong Chen, Ann Moriarty, Qing Yang   +8 more
openaire   +5 more sources

Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase [PDF]

J Theor Biol 240: 464-474 (2006), 2005
Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 ...
Akesson, Baker, Barkai, Borgmann, Dang, Fan, Ferea, Goodacre, Griffiths, Gross, Joel R. Sevinsky, Joshua Downer, Jungmann, Kal, Karan, Katheryn A. Resing, Kim, Kitano, Kondoh, Koslowski, Koukourakis, Lambeth, Lewis, Lewis, Li, M.D. Betterton, Maekawa, Mazurek, Mulquiney, Munoz-Pinedo, Natalie G. Ahn, Newell, Osthus, Papas, Press, Riera, Segal, Sevinsky, Shim, Stambaugh, Stephanopoulos, Stubbs, Tilton, Unwin, Voet, von Dassow, Walenta, Warburg   +47 more
core   +2 more sources