Results 201 to 210 of about 1,035,719 (353)

Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a Potent p38 MAP Kinase Inhibitor [PDF]

, 2014
Toru Asano, Hitoshi Yamazaki, Chiyoshi Kasahara, Hirokazu Kubota, Toru Kontani, Yu Harayama, Kazuki Ohno, Hidekazu Mizuhara, Masaharu Yokomoto, Keiji Misumi, Tomohiko Kinoshita, Ohta Mitsuaki, Makoto Takeuchi   +12 more
openalex   +1 more source

Supplementary Table 4 from Unfolded Protein Response Signaling and MAP Kinase Pathways Underlie Pathogenesis of Arsenic-Induced Cutaneous Inflammation [PDF]

, 2023
Changzhao Li, Jianmin Xu, Fugui Li, Sandeep Chaudhary, Zhiping Weng, Jianming Wen, Craig A. Elmets, Habibul Ahsan, Mohammad Athar   +8 more
openalex   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Sodium Methyldithiocarbamate Inhibits MAP Kinase Activation through Toll-like Receptor 4, Alters Cytokine Production by Mouse Peritoneal Macrophages, and Suppresses Innate Immunity [PDF]

, 2005
Stephen B. Pruett, Qiang Zheng, Carlton L. Schwab, Ruping Fan   +3 more
openalex   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

The coupling of α₆β₄integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation

, 1997
Fabrizio Mainiero, Chiara Murgia, Kishore K. Wary, Anna Maria Curatola, Angela Pepe, Miroslav Blumemberg, John Westwick, Channing J. Der, Filippo G. Giancotti   +8 more
openalex   +2 more sources

Syndecan‐4 regulates platelet‐derived growth factor‐mediated MAP kinase activation by altering intracellular reactive oxygen species [PDF]

, 2008
Jungyean Kim, Jung‐Hyun Lee, Hey Sun Park, Jisun Hwang, Inn‐Oc Han, Yun Soo Bae, Eok‐Soo Oh   +6 more
openalex   +1 more source

Medicinal Chemistry Strategies in Targeting TGF-βR1 Kinase Domain: Unveiling Insights into Inhibitor Structure-Activity Relationship (SAR). [PDF]

Pharmaceuticals (Basel)
Babiker NA, Nadeem S, Abu Kariem H, Abdul Hameed A, Negmeldin AT, El-Labbad EM.   +5 more
europepmc   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Fibroblast growth factors 1 and 2 differently activate MAP kinase in Xenopus oocytes expressing fibroblast growth factor receptors 1 and 4

, 2001
Katia Cailliau, Edith Browaeys‐Poly, Jean Pierre Vilain   +2 more
openalex   +1 more source