Results 251 to 260 of about 649,548 (363)

Activation of MAP kinase family members triggered by TPA or ionomycin occurs via the protein phosphatase�4 pathway in Jurkat leukemia T cells

, 2011
Eduardo Parra
openalex   +2 more sources

Phosphorylation of Atg5 by the Gadd45β–MEKK4-p38 pathway inhibits autophagy

Cell Death and Differentiation, 2012
E. Keil, R. Höcker, M. Schuster, F. Essmann, N. Ueffing, N. Ueffing, B. Hoffman, D. Liebermann, K. Pfeffer, K. Schulze-Osthoff, I. Schmitz   +10 more
semanticscholar   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

A self-supervised machine learning pipeline for extracting information from live cell images at multiple doses and timepoints. [PDF]

Sci Rep
Isaev DY, Liu WP, Cuevas M, Tang Y, Ang K, Wilson C, Mai Q, Adra J, Cruz A, Nguyen K, Ricasa M, Gupta A, Hamadani M, Sridharan D, Yeghiazarians Y, Ameri K.   +15 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Early G1 Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma

Clinical Cancer Research, 2011
A. Ismail, Santhoshi Bandla, Marie Réveiller, L. Toia, Zhongren Zhou, W. Gooding, Irina Kalatskaya, Lincoln D. Stein, Mary D’souza, V. Litle, J. Peters, A. Pennathur, J. Luketich, T. Godfrey   +13 more
semanticscholar   +1 more source

Structural Rationalization of IPMK Inhibitor Potency. [PDF]

J Med Chem
Wang H, Shears SB, Blind RD.
europepmc   +1 more source

Using bioinformatics and artificial intelligence to map the cyclin-dependent kinase 4/6 inhibitor biomarker landscape in breast cancer [PDF]

Kim Wager, Yao Wang, Andrew T. F. Liew, Dean Campbell, Feng Liu, Jean-François Martini, Niusha Ziaee, Yuan Liu   +7 more
openalex   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Molecular identifiers of the evolutionarily conserved titin pseudokinase. [PDF]

Biochem J
Dorendorf T, Gravenhorst P, Mayans O.
europepmc   +1 more source