Cytokine upregulation of proteinase‐activated‐receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinaseβin human endothelial cells [PDF]
British Journal of Pharmacology, 2007 Background and purpose:Up‐regulation of proteinase‐activated receptor‐2 (PAR2) is a factor in a number of disease states and we have therefore examined the signalling pathways involved in the expression of the receptor.Experimental approach:We investigated the effects of tumour necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), trypsin and the PAR2 ...
E Ritchie +6 more
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MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. [PDF]
Molecular Cell, 1999 In C. elegans, a Wnt/WG-like signaling pathway down-regulates the TCF/LEF-related protein, POP-1, to specify posterior cell fates. Effectors of this signaling pathway include a beta-catenin homolog, WRM-1, and a conserved protein kinase, LIT-1. WRM-1 and LIT-1 form a kinase complex that can directly phosphorylate POP-1, but how signaling activates WRM ...
T. Shin +9 more
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Life Sciences, 2014 We previously reported that bone morphogenetic protein-4 (BMP-4) stimulates the synthesis of osteocalcin via p38 mitogen-activated protein (MAP) kinase in osteoblast-like MC3T3-E1 cells, whereas p44/p42 MAP kinase plays as a negative regulator in the synthesis.
章 近藤
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Biotech Today : An International Journal of Biological Sciences, 2016 Arabidopsis thaliana was shown to be an alternate host plant for the disease, Alternaria blight of Brassica and used as a model plant to delineate the relationship between MAP Kinase 4 (MAPK4) and MAP Kinase 6 (MAPK6) during pathogenesis of Alternaria blight.
Rakesh Mondal +3 more
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Platelet factor 4 (PF-4)–induced neutrophil adhesion is controlled by src-kinases, whereas PF-4–mediated exocytosis requires the additional activation of p38 MAP kinase and phosphatidylinositol 3-kinase [PDF]
Blood, 2003 AbstractAmong the various chemokines that are functionally active on neutrophils, platelet factor 4 (PF-4; CXCL4) appears to have a specialized role. Lacking typical chemokine activities, PF-4 stimulates neutrophils to undergo firm adhesion to endothelial cells and, in the presence of an appropriate costimulus like tumor necrosis factor (TNF), PF-4 ...
Brigitte Kasper +3 more
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Epitope Mapping of the Anti-Diacylglycerol Kinase Monoclonal Antibody DhMab-4 for Immunohistochemical Analysis [PDF]
Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2020 Diacylglycerol kinase (DGK) plays a pivotal role in intracellular signaling pathways in mammals. Activated G protein-coupled receptor activates phospholipase C (PLC) through heterotrimeric G protein, following which PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP 2 ) into ...
Teizo, Asano +5 more
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, 2023 Supplementary Figures 1-4 from MAP Kinase-Interacting Kinase 1 Regulates SMAD2-Dependent TGF-β Signaling Pathway in Human ...
Michal Grzmil +7 more
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Computational and Structural Biotechnology Journal, 2020 Protein kinases are crucial components of the cell-signalling machinery that orchestrate and convey messages to their downstream targets. Most often, kinases are activated upon a phosphorylation to their activation loop, which will shift the kinase into ...
Ekaterina Shevchenko +2 more
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BWMK1, a Novel MAP Kinase Induced by Fungal Infection and Mechanical Wounding in Rice
Molecular Plant-Microbe Interactions, 1999 The activation of the mitogen-activated protein (MAP) kinases by different environmental stresses has been previously observed in several dicot plant species. Here, we report the isolation of a novel MAP kinase in rice that is induced during infection by
Chaozu He +3 more
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Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: Effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity [PDF]
, 2006 Sub-lethal concentrations of the organophosphate phenyl saligenin phosphate (PSP) inhibited the outgrowth of axon-like processes in differentiating mouse N2a neuroblastoma cells (IC50 2.5 μM).
Abou-Donia +56 more
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