Results 31 to 40 of about 649,548 (363)

Nitric Oxide/cGMP Signaling Pathway Protects RAW264 Cells Against Nitric Oxide-Induced Apoptosis by Inhibiting the Activation of p38 Mitogen-Activated Protein Kinase

Journal of Pharmacological Sciences, 2006
.: Nitric oxide (NO) induces apoptosis in various cells lines, while activation of the NO/cGMP signaling pathway prevents apoptosis induced by diverse stimuli, including NO.
Yoshioka Yasuhiro, Yamamuro Akiko, Keun-A Sadaaki   +2 more
doaj   +1 more source

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

Erythropoietin‐activated ERK/MAP kinase enhances GATA‐4 acetylation via phosphorylation of serine 261 of GATA‐4

Journal of Cellular Physiology, 2012
AbstractGATA‐4, a zinc finger transcription factor, plays a critical role in heart development. Previous studies have shown that p300‐targeted GATA‐4 acetylation increases GATA‐4 stability and transcriptional activity, which then stimulates hypertrophy of cardiomyocyte.
Ji Hae Jun, Jae‐Kwang Shim, Hyun‐Mo Ryoo, Young Lan Kwak   +3 more
openalex   +5 more sources

Registered report: Diverse somatic mutation patterns and pathway alterations in human cancers

eLife, 2016
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers,
Vidhu Sharma, Lisa Young, Anne B Allison, Kate Owen, Reproducibility Project: Cancer Biology   +4 more
doaj   +1 more source

Group V Phospholipase A2 Induces Leukotriene Biosynthesis in Human Neutrophils through the Activation of Group IVA Phospholipase A2 [PDF]

, 2002
We reported previously that exogenously added human group V phospholipase A2 (hVPLA2) could elicit leukotriene B4 (LTB4) biosynthesis in human neutrophils (Han, S. K., Kim, K. P., Koduri, R., Bittova, L., Munoz, N. M., Leff, A. R., Wilton, D. C., Gelb, M.
Cho, Wonhwa, Han, Sang Kyou, Kim, Kwang Pyo, Kim, Young Jun, Leff, Alan R., Munoz, Nilda M., Sano, Hiroyuki, Zhu, Xiangdong   +7 more
core   +1 more source

Prostaglandin E2 prevents hyperosmolar-induced human mast cell activation through prostanoid receptors EP2 and EP4. [PDF]

PLoS ONE, 2014
BACKGROUND: Mast cells play a critical role in allergic and inflammatory diseases, including exercise-induced bronchoconstriction (EIB) in asthma. The mechanism underlying EIB is probably related to increased airway fluid osmolarity that activates mast ...
Ivonne Torres-Atencio, Erola Ainsua-Enrich, Fernando de Mora, César Picado, Margarita Martín   +4 more
doaj   +1 more source

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition [PDF]

, 2014
BRAFV600E-mutant malignant melanomas depend on RAF/MEK/ERK (MAPK) signaling for tumor cell growth1. RAF and MEK inhibitors show remarkable clinical efficacy in BRAFV600E melanoma2, 3; however, resistance to these agents remains a formidable challenge2, 4.
Donahue, Melanie K., Flaherty, Keith T., Frederick, Dennie T., Garraway, Levi A., Johannessen, Cory M., Johnson, Laura A., Narayan, Rajiv, Piccioni, Federica, Root, David E., Townes, Aisha, Wargo, Jennifer A.   +10 more
core   +1 more source

Design and Synthesis of 4-Azaindoles as Inhibitors of p38 MAP Kinase

Journal of Medicinal Chemistry, 2003
Inhibition of the biosynthesis of proinflammatory cytokines such as tumor necrosis factor and interleukin-1 via p38 has been an approach toward the development of a disease modifying agent for the treatment of chronic inflammation and autoimmune diseases.
Alejandra Trejo, Humberto Arzeno, Michelle F. Browner, Sushmita Chanda, Soan Cheng, Daniel D. Comer, Stacie A. Dalrymple, Pete Dunten, JoAnn LaFargue, Brett Lovejoy, José Freire-Moar, Julie Lim, Joel McIntosh, Jennifer Miller, Eva Papp, Deborah C. Reuter, Rick Roberts, Florentino Sanpablo, John Saunders, Kyung Song, Armando G. Villaseñor, Stephen D. Warren, Mary Welch, Paul Weller, Phyllis E. Whiteley, Lu Zeng, David Goldstein   +26 more
openalex   +3 more sources

Dual Specificity Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Plays a Potential Role in Insulin Resistance [PDF]

Journal of Biological Chemistry, 2003
Insulin is the key hormone that controls glucose homeostasis. Dysregulation of insulin function causes diabetes mellitus. Among the two major forms of diabetes, type 2 diabetes accounts for over 90% of the affected population. The incidence of type 2 diabetes is highly related to obesity.
Haiyan Xu, Marlene Dembski, Qing Yang, Daseng Yang, A Moriarty, Olga Tayber, Hong Chen, Rosana Kapeller, Louis A. Tartaglia   +8 more
openalex   +4 more sources

Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

Journal of Hematology & Oncology, 2019
BackgroundAdenylate kinase 4 (AK4) has been identified as a biomarker of metastasis in lung cancer. However, the impacts of AK4 on metabolic genes and its translational value for drug repositioning remain unclear.MethodsIngenuity upstream analyses were ...
Y. Jan, T. Lai, Chih-Jen Yang, Yuan-Feng Lin, Ming-Shyan Huang, M. Hsiao   +5 more
semanticscholar   +1 more source