Results 31 to 40 of about 1,035,719 (353)

Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development

Scientific Reports, 2022
Coordinating the balance between development and stress responses is critical for organismal survival. However, the cellular signaling controlling this mechanism is not well understood.
Rose Aria Malinow, Ming Zhu, Yishi Jin, Kyung Won Kim   +3 more
doaj   +1 more source

Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: Effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity [PDF]

, 2006
Sub-lethal concentrations of the organophosphate phenyl saligenin phosphate (PSP) inhibited the outgrowth of axon-like processes in differentiating mouse N2a neuroblastoma cells (IC50 2.5 μM).
Abou-Donia, Abou-Donia, Alan J. Hargreaves, Barber, Barber, Brunet, Casida, Chambers, Denizot, Ehrich, El-Fawal, Eto, Flaskos, Flaskos, Forshaw, Fowler, Glynn, Glynn, Gupta, Hatch, Henschler, Ian C. Coutts, James, Jensen, John Flaskos, Johnson, Johnson, Johnson, Jortner, Jortner, Keilbaugh, Laemmli, Lee, Li, Lowry, Magdalini Sachana, Mary Bountouri, Maxine J. Fowler, Nixon, Nomeir, Nomeir, Nostrandt, Nostrandt, Paul Glynn, Perron, Rosenstock, Schmuck, Sharma, Song, Suwita, Towbin, Van Teinhoven, Veeranna, Veronesi, W. Graham McLean, Wayne Harris, Zhao   +56 more
core   +1 more source

BWMK1, a Novel MAP Kinase Induced by Fungal Infection and Mechanical Wounding in Rice

Molecular Plant-Microbe Interactions, 1999
The activation of the mitogen-activated protein (MAP) kinases by different environmental stresses has been previously observed in several dicot plant species. Here, we report the isolation of a novel MAP kinase in rice that is induced during infection by
Chaozu He, Steven Haw Tien Fong, Daichang Yang, Guo-Liang Wang   +3 more
doaj   +1 more source

Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes [PDF]

, 1993
ET-1 stimulated MBP kinase activity in cultured cardiomyocytes. Maximal activation (3.5-fold) was at 5 min. EC50 was 0.2 nM. PMA or PE also increased MBP kinase (4- or 2.5-fold, respectively). Pre-treatment with PMA down-regulated the subsequent response
Bogoyevitch, Marie A., Glennon, Peter E., Sugden, Peter H.   +2 more
core   +1 more source

Oxidation and phosphorylation of MAP kinase 4 cause protein aggregation

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2015
Mitogen-activated protein kinase (MPK) cascades are highly conserved signaling pathways that respond to environmental cues. Arabidopsis MPK4 has been identified as a stress-responsive protein kinase. Here we demonstrate that Brassica napus MPK4 (BnMPK4) is activated by hydrogen peroxide (H2O2) and phytohormone abscisic acid (ABA).
Tong, Zhang, Zhang, Tong, Zhu, Mengmeng, Song, Wen-yuan, Harmon, Alice C., Chen, Sixue   +5 more
openaire   +4 more sources

mRNP3 and mRNP4 are phosphorylatable by casein kinase II in Xenopus oocytes, but phosphorylation does not modify RNA-binding affinity [PDF]

, 1997
mRNP3 and mRNP4 (also called FRGY2) are two mRNA-binding proteins which are major constituents of the maternal RNA storage particles of Xenopus laevis oocytes. The phosphorylation of mRNP3–4 has been implicated in the regulation of mRNA masking.
Dautry, François, Deschamps, Stéphane, Jacquemin-Sablon, Hélène, Le Caer, Jean-Pierre, le Maire, Marc, Mulner-Lorillon, Odile, Potier, Michel, Triqueneaux, Gérard   +7 more
core   +1 more source

Registered report: Diverse somatic mutation patterns and pathway alterations in human cancers

eLife, 2016
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers,
Vidhu Sharma, Lisa Young, Anne B Allison, Kate Owen, Reproducibility Project: Cancer Biology   +4 more
doaj   +1 more source

Prediction of kinase inhibitor response using activity profiling, in-vitro screening, and elastic net regression [PDF]

BMC Systems Biology 2014, 8:74, 2013
Many kinase inhibitors have been approved as cancer therapies. Recently, libraries of kinase inhibitors have been extensively profiled, thus providing a map of the strength of action of each compound on a large number of its targets. These profiled libraries define drug-kinase networks that can predict the effectiveness of new untested drugs and ...
arxiv   +1 more source

Glutathione S-Transferase p Elicits Protection against H2O2-induced Cell Death via Coordinated Regulation of Stress Kinases [PDF]

, 2000
To elucidate mechanisms underlying glutathione S-transferase p (GSTp)-mediated cellular protection against oxidative stress-induced cell death, the effect of GSTp on stress signaling pathways was investigated before and after H2O2 treatment.
Habelhah, Hasem, Ivanov, Vladimir N., Ronai, Ze'ev, Tew, Kenneth, Yin, Zhimin   +4 more
core   +2 more sources

Effect of Chitosan Composite Preservative on Proteome Changes of Grass Carp Muscle during Cold Storage [PDF]

Shipin Kexue, 2023
To explore the effect of a chitosan-based preservative solution (10 mg/mL chitosan + 5 mg/mL tea polyphenol + 2 000 U/mL lysozyme) on the change in the muscle proteome of grass carp during cold storage, differential proteomic analysis of fresh fish and ...
LI Jialei, CHEN Sai, TIAN Mingli, YU Jian, LIU Yongle, WANG Faxiang
doaj   +1 more source