Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins [PDF]
PLoS Comput Biol. 2008 Jun 27;4(6):e1000099, 2008 Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well ...
arxiv +1 more source
Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: Involvement of src family protein kinases [PDF]
, 2002 The increased production of amyloid beta -peptide (A beta) in Alzheimer's disease is acknowledged to be a key pathogenic event. In this study, we examined the response of primary human and rat brain cortical cultures to A beta administration and found a ...
Anderton, B. H. +10 more
core +1 more source
Involvement of p38 MAPK and ERK/MAPK pathways in staurosporine-induced production of macrophage inflammatory protein-2 in rat peritoneal neutrophils [PDF]
, 1999 Stimulation of rat peritoneal neutrophils with staurosporine (64 nM) induced production of macrophage inflammatory protein-2 (MIP-2) and phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase/MAP kinase ...
Morita, Hiroyuki +4 more
core +1 more source
Molecules, 2017 In vitro and in vivo metabolism studies revealed that 2-alkylsulfanylimidazole ML3403 (4-(5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl)-N-(1-phenylethyl)pyridin-2-amine) undergoes rapid oxidation to the sulfoxide.
Fabian Heider +7 more
doaj +1 more source
Studies about the participation of the transcriptionsfactor CREB in the model LTP in the hippocampal formation of the rat [PDF]
, 2002 Titelblatt, Inhaltsverzeichnis, Lebenslauf 1\. Einleitung 2\. Eigene Untersuchungen 3.1 Ergebnisse Teil 1 3.2 Ergebnisse Teil 2 3.3 Ergebnisse Teil 3 4\. Diskussion 5\.
Siemer, Helge
core +1 more source
Antioxidants, 2021 Dysregulated glutamate signaling, leading to neuronal excitotoxicity and death, has been associated with neurodegenerative pathologies. 17β-estradiol (E2) is a human steroid hormone having a role in reproduction, sexual maturation, brain health and ...
Ibrahim Khan +3 more
doaj +1 more source
Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 [PDF]
, 2017 The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-G. However, the regulation of ERK3 and ERK4 phosphorylation and activity is poorly understood.
A De la Mota-Peynado +35 more
core +4 more sources
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition [PDF]
, 2014 BRAFV600E-mutant malignant melanomas depend on RAF/MEK/ERK (MAPK) signaling for tumor cell growth1. RAF and MEK inhibitors show remarkable clinical efficacy in BRAFV600E melanoma2, 3; however, resistance to these agents remains a formidable challenge2, 4.
Donahue, Melanie K. +10 more
core +1 more source
The genetic landscape of ganglioglioma
Acta Neuropathologica Communications, 2018 Ganglioglioma is the most common epilepsy-associated neoplasm that accounts for approximately 2% of all primary brain tumors. While a subset of gangliogliomas are known to harbor the activating p.V600E mutation in the BRAF oncogene, the genetic ...
Melike Pekmezci +24 more
doaj +1 more source
Mapping of Functional Domains of the Lipid Kinase Phosphatidylinositol 4-Kinase Type III Alpha Involved in Enzymatic Activity and Hepatitis C Virus Replication [PDF]
Journal of Virology, 2014 ABSTRACT The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an endoplasmic reticulum (ER)-resident enzyme that synthesizes phosphatidylinositol 4-phosphate (PI4P). PI4KIIIα is an essential host factor for hepatitis C virus (HCV) replication.
Cyntia Taveneau +6 more
openaire +3 more sources