Results 51 to 60 of about 1,035,719 (353)

Investigation of LKB1 Ser⁴³¹ phosphorylation and Cys⁴³³ farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity [PDF]

, 2014
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser(431)
Alessi, Alessi, Alessi, Andrade-Vieira, Baas, Barnes, Bayascas, Boudeau, Boudeau, Boutin, Carling, Carling, Chen, Clark, Collins, Corton, Dario R. Alessi, Davisson, Denison, Denison, Farnsworth, Fogarty, Fogarty, Foretz, Gwinn, Hardie, Hardie, Hawley, Hayashi, Hemminki, Henriksson, Hunter, Jansen, Jeppesen, Ji, Joby Varghese, Kei Sakamoto, Kishi, Koh, Komander, Liu, Lizcano, Maria Stella Ritorto, Martin, McLaughlin, Mitchelhill, Moores, Mora, Najafov, Nakada, Natalia Shpiro, Oakhill, Paul Davies, Robert Gourlay, Sakamoto, Sakamoto, Sakamoto, Sanchez-Cespedes, Sanchez-Cespedes, Sanders, Sapkota, Sapkota, Screaton, Shaw, Shelly, Su, Towler, Vanessa P. Houde, Vavvas, Viollet, Wiggin, Woods, Wullschleger, Zagorska, Zeqiraj, Zeqiraj, Zhang   +76 more
core   +1 more source

The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation [PDF]

Cellular Signalling, 2005
2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid (PACA), pharmacological inhibitor of phospholipase A(2) (PLA(2)), inhibits epinephrine-stimulated thromboxane production in human platelets. In this study, we investigated the effect of PACA on meiotic maturation individually in stages V and VI oocytes.
Isamu Sugimoto, Satoshi Yoshitome, Kazuo Yamada, Ellen K. Shibuya, Eikichi Hashimoto, Yoko Sakamoto, Kazuhisa Kosaka, Azharul Islam, George F. Vande Woude   +8 more
openaire   +3 more sources

An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients [PDF]

, 2008
Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters.
Bartlett, J.M.S., Edwards, J., Grimsley, S.L.S., McGlynn, L.M., Mukherjee, R., Traynor, P.   +5 more
core   +3 more sources

Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways

Respiratory Research, 2009
Background Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser (RGDS) peptide on key inflammatory responses to intratracheal (i.t ...
Hah Jong, Park Hyun-Jung, Han Jeong, Moon Changsuk, Kang Jihee   +4 more
doaj   +1 more source

CRAF R391W is a melanoma driver oncogene. [PDF]

, 2016
Approximately 75% of melanomas have known driver oncogenic mutations in BRAF, NRAS, GNA11 or GNAQ, while the mutations providing constitutive oncogenic signaling in the remaining melanomas are not known.
Atefi, Mohammad, Avramis, Earl, Chmielowski, Bartosz, Friedman, Michael, Graeber, Thomas G, Lassen, Amanda, Le, Allison, Lomova, Anastasia, Ng, Charles, Ribas, Antoni, Titz, Bjoern, Tsoi, Jennifer   +11 more
core   +3 more sources

Arabidopsis MKS1 is involved in basal immunity and requires an intact N-terminal domain for proper function. [PDF]

PLoS ONE, 2010
Innate immune signaling pathways in animals and plants are regulated by mitogen-activated protein kinase (MAPK) cascades. MAP kinase 4 (MPK4) functions downstream of innate immune receptors via a nuclear substrate MKS1 to regulate the activity of the ...
Klaus Petersen, Jin-Long Qiu, Juri Lütje, Berthe Katrine Fiil, Sidsel Hansen, John Mundy, Morten Petersen   +6 more
doaj   +1 more source

Estimation of kinetic rates of MAP kinase activation from experimental data [PDF]

, 2009
Mathematical model is an important tool in systems biology to study the dynamics of biological systems inside the cell. One of the significant challenges in systems biology is the lack of kinetic rates that should be measured in experiments or estimated ...
Tian, T.
core   +1 more source

Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates Its Nitrosative-Stress-Specific Outputs [PDF]

, 2018
Data availability. The RNA sequencing dataset is available at EBI (www.ebi.ac.uk/arrayexpress/) under accession number E-MTAB-5990. Other data that support the findings of this study are available from the corresponding author upon reasonable request ...
Alison M. Day, Alistair J. P. Brown, Anna T. Tillmann, Carmen Herrero-de-Dios, David Stead, Janet Quinn, Michael Lorenz, Paula S. Salgado, Stavroula L. Kastora   +8 more
core   +2 more sources

Leishmania donovani Secretory Mevalonate Kinase Regulates Host Immune Response and Facilitates Phagocytosis

Frontiers in Cellular and Infection Microbiology, 2021
Summary StatementLeishmania secretes over 151 proteins during in vitro cultivation. Cellular functions of one such novel protein: mevalonate kinase is discussed here; signifying its importance in Leishmania infection.Visceral Leishmaniasis is a ...
Tanvir Bamra, Taj Shafi, Sushmita Das, Manjay Kumar, Manas Ranjan Dikhit, Ajay Kumar, Ashish Kumar, Kumar Abhishek, Krishna Pandey, Abhik Sen, Pradeep Das   +10 more
doaj   +1 more source

A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-Term Potentiation [PDF]

, 2006
The induction of late long-term potentiation (L-LTP) involves complex interactions among second messenger cascades. To gain insights into these interactions, a mathematical model was developed for L-LTP induction in the CA1 region of the hippocampus. The differential equation-based model represents actions of protein kinase A (PKA), MAP kinase (MAPK ...
arxiv   +1 more source