Results 61 to 70 of about 649,548 (363)

Arabidopsis MKS1 is involved in basal immunity and requires an intact N-terminal domain for proper function. [PDF]

PLoS ONE, 2010
Innate immune signaling pathways in animals and plants are regulated by mitogen-activated protein kinase (MAPK) cascades. MAP kinase 4 (MPK4) functions downstream of innate immune receptors via a nuclear substrate MKS1 to regulate the activity of the ...
Klaus Petersen, Jin-Long Qiu, Juri Lütje, Berthe Katrine Fiil, Sidsel Hansen, John Mundy, Morten Petersen   +6 more
doaj   +1 more source

MAP kinase is involved in IL-4 dependent cytokine expression by human intestinal mast cells

Journal of Allergy and Clinical Immunology, 2002
SC Bischoff, Mikosch Wilke, MP Manns, Axel Lorentz   +3 more
openalex   +2 more sources

Role of G Protein-coupled Receptor Kinase 4 and β-Arrestin 1 in Agonist-stimulated Metabotropic Glutamate Receptor 1 Internalization and Activation of Mitogen-activated Protein Kinases*

Journal of Biological Chemistry, 2003
The metabotropic glutamate 1 (mGlu1) receptor in cerebellar Purkinje cells plays a key role in motor learning and motor coordination. Here we show that the G protein-coupled receptor kinases (GRK) 2 and 4, which are expressed in these cells, regulate the
L. Iacovelli, L. Salvatore, L. Capobianco, A. Picascia, E. Barletta, M. Storto, S. Mariggiò, M. Sallese, A. Porcellini, F. Nicoletti, A. de Blasi   +10 more
semanticscholar   +1 more source

Inhibition of the TNF-α–Induced Serine Phosphorylation of IRS-1 at 636/639 by AICAR

Journal of Pharmacological Sciences, 2013
AMP-activated protein kinase (AMPK) contributes to the acceleration of insulin signaling. However, the mechanism by which AMPK regulates insulin signaling remains unclear.
Tomohito Shibata, Akira Takaguri, Kazuo Ichihara, Kumi Satoh   +3 more
doaj   +1 more source

Leishmania donovani Secretory Mevalonate Kinase Regulates Host Immune Response and Facilitates Phagocytosis

Frontiers in Cellular and Infection Microbiology, 2021
Summary StatementLeishmania secretes over 151 proteins during in vitro cultivation. Cellular functions of one such novel protein: mevalonate kinase is discussed here; signifying its importance in Leishmania infection.Visceral Leishmaniasis is a ...
Tanvir Bamra, Taj Shafi, Sushmita Das, Manjay Kumar, Manas Ranjan Dikhit, Ajay Kumar, Ashish Kumar, Kumar Abhishek, Krishna Pandey, Abhik Sen, Pradeep Das   +10 more
doaj   +1 more source

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]

, 2016
BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus, Maung, Ricky, Medders, Kathryn E, Ojeda-Juárez, Daniel, Sanchez, Ana B, Sánchez-Pavón, Paloma   +5 more
core   +1 more source

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

eLife, 2017
The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood.
Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins   +14 more
doaj   +1 more source

Deciphering MAP kinase pathway in Cicer arietinum upon Helicoverpa armigera -infestation

Plant Stress
The activation of Mitogen-Activated Protein Kinase (MAPK) pathway is recognized as a key regulator of the plant defense mechanisms in response to insect attacks.
Mansi Taneja, Kalpesh Nath Yajnik, Megha Kumari, Indrakant Kumar Singh, Archana Singh   +4 more
doaj   +1 more source

Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.

PLoS ONE, 2008
TRPM6 and TRPM7 are bifunctional proteins expressing a TRP channel fused to an atypical alpha-kinase domain. While the gating properties of TRPM6 and TRPM7 channels have been studied in detail, little is known about the mechanisms regulating kinase ...
Kristopher Clark, Jeroen Middelbeek, Nick A Morrice, Carl G Figdor, Edwin Lasonder, Frank N van Leeuwen   +5 more
doaj   +1 more source

Targeting apoptosis signalling kinase-1 (ASK-1) does not prevent the development of neuropathy in streptozotocin-induced diabetic mice. [PDF]

PLoS ONE, 2014
Apoptosis signal-regulating kinase-1 (ASK1) is a mitogen-activated protein 3 kinase (MAPKKK/MAP3K) which lies upstream of the stress-activated MAPKs, JNK and p38. ASK1 may be activated by a variety of extracellular and intracellular stimuli.
Victoria L Newton, Sumia Ali, Graham Duddy, Alan J Whitmarsh, Natalie J Gardiner   +4 more
doaj   +1 more source