Results 81 to 90 of about 1,035,719 (353)

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus Egg Extracts Requires Binding of ATRIP to ATR but Not the Stable DNA-binding or Coiled-coil Domains of ATRIP [PDF]

, 2005
ATR, a critical regulator of DNA replication and damage checkpoint responses, possesses a binding partner called ATRIP. We have studied the functional properties of Xenopus ATR and ATRIP in incubations with purified components and in frog egg extracts ...
Dunphy, William G., Kim, Soon-Mi, Kumagai, Akiko, Lee, Joon   +3 more
core   +2 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Impact of glioblastoma multiforme associated mutations on the structure and function of MAP/microtubule affinity regulating kinase 4

Journal of Biomolecular Structure and Dynamics, 2020
MAP/Microtubule affinity regulating kinase 4 (MARK4) plays an important role in the regulation of microtubule dynamics by phosphorylation of tau protein. A higher expression of MARK4 is observed in the glioblastoma multiforme (GBM) cell lines. We identified eight synonymous and non-synonymous mutations in the MARK4 gene related to GBM in The Cancer ...
Ahmad Abu Turab Naqvi, Deeba Shamim Jairajpuri, Afzal Hussain, Gulam Mustafa Hasan, Mohamed F. Alajmi, Md. Imtaiyaz Hassan   +5 more
openaire   +4 more sources

Structural insights into characterizing binding sites in EGFR kinase mutants [PDF]

Journal of Chemical Information and Modeling, 2018, 2018
Over the last two decades epidermal growth factor receptor (EGFR) kinase has become an important target to treat non-small cell lung cancer (NSCLC). Currently, three generations of EGFR kinase-targeted small molecule drugs have been FDA approved. They nominally produce a response at the start of treatment and lead to a substantial survival benefit for ...
arxiv   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Nitric Oxide/cGMP Signaling Pathway Protects RAW264 Cells Against Nitric Oxide-Induced Apoptosis by Inhibiting the Activation of p38 Mitogen-Activated Protein Kinase

Journal of Pharmacological Sciences, 2006
.: Nitric oxide (NO) induces apoptosis in various cells lines, while activation of the NO/cGMP signaling pathway prevents apoptosis induced by diverse stimuli, including NO.
Yoshioka Yasuhiro, Yamamuro Akiko, Keun-A Sadaaki   +2 more
doaj  

Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways

Frontiers in Pharmacology, 2022
Cinnamomum zeylanicum is a tropical plant with traditional medicinal significance that possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties.
Sadhna Aggarwal, Kanchan Bhadana, Baldeep Singh, Meenakshi Rawat, Taj Mohammad, Lamya Ahmed Al-Keridis, Nawaf Alshammari, Md. Imtaiyaz Hassan, Satya N. Das   +8 more
doaj   +1 more source

4‐Methylcatechol stimulates phosphorylation of Trk family neurotrophin receptors and MAP kinases in cultured rat cortical neurons [PDF]

Journal of Neuroscience Research, 2002
AbstractEffects of 4‐methycatechol (4MC), a potent stimulator of nerve growth factor and brain‐derived neurotrophic factor (BDNF) synthesis, on phosphorylation of cellular molecules in cultured rat cortical neurons were examined. 4MC stimulated tyrosine phosphorylation of various proteins of molecular weight from 10–300 kDa including Trks, which are ...
Shoei Furukawa, Hiroshi Nomoto, Ayako Sometani, Yoshiko Furukawa, Atsumi Nitta   +4 more
openaire   +3 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Suppression of MAP4K4 Signaling Ameliorates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis-Molecular Studies Toward New Therapeutics

Journal of Experimental Neuroscience, 2019
Amyotrophic lateral sclerosis (ALS), the most common motor neuron (MN) disease of adults, is characterized by the degeneration of upper MNs in the motor cortex and lower MNs in the brain stem and spinal cord.
Michelle E Watts, Chen Wu, Lee L Rubin
doaj   +1 more source