Results 1 to 10 of about 518,432 (294)

Kinase Hog1 and Adr1 Opposingly Regulate Haploid Cell Morphology by Controlling Vacuole Size in Sporisorium scitamineum

Journal of Fungi, 2022
Morphogenesis is a strictly regulated efficient system in eukaryotes for adapting to environmental changes. However, the morphogenesis regulatory mechanism in smut fungi is not clear.
Enping Cai, Meixin Yan, Xian Sun, Rong Zeng, Wenqiang Zheng, Yizhen Deng, Zide Jiang, Changqing Chang   +7 more
doaj   +1 more source

HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts. [PDF]

PLoS ONE, 2017
Heat shock protein 90 (HSP90) that is ubiquitously expressed in various tissues, is recognized to be a major molecular chaperone. We have previously reported that prostaglandin F2α (PGF2α), a potent bone remodeling mediator, stimulates the synthesis of ...
Kazuhiko Fujita, Haruhiko Tokuda, Gen Kuroyanagi, Naohiro Yamamoto, Shingo Kainuma, Tetsu Kawabata, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka   +9 more
doaj   +1 more source

Regulatory role of some protein kinases in signal transduction pathways in heart health and disease [PDF]

Scripta Medica, 2023
Various protein kinases including protein kinase A (PKA), Ca2+-calmodulin kinase (CaMK), phosphoinositide 3-kinase (PI3K), protein kinase C (PKC) and mitogen-activated protein kinase (MAPK: ERK1/2, p38-MAPK and JNK) are integral part of different signal ...
Nusier Mohamad, Elimban Vijayan, Prasad Jaykishan, Shah Anureet K., Dhalla Naranjan S.   +4 more
doaj  

Control of signaling in a MAP-kinase pathway by an RNA-binding protein. [PDF]

PLoS ONE, 2007
Signaling-protein mRNAs tend to have long untranslated regions (UTRs) containing binding sites for RNA-binding proteins regulating gene expression.
Susanne Prinz, Christine Aldridge, Stephen A Ramsey, R James Taylor, Timothy Galitski   +4 more
doaj   +1 more source

HSP22 (HSPB8) positively regulates PGF2α-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts

Journal of Orthopaedic Surgery and Research, 2021
Background Heat shock protein 22 (HSP22) belongs to class I of the small HSP family that displays ubiquitous expression in osteoblasts. We previously demonstrated that prostaglandin F2α (PGF2α), a potent bone remodeling factor, induces the synthesis of ...
Gen Kuroyanagi, Go Sakai, Takanobu Otsuka, Naohiro Yamamoto, Kazuhiko Fujita, Tetsu Kawabata, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda   +8 more
doaj   +1 more source

The MAP Kinase Kinase MKK2 Affects Disease Resistance in Arabidopsis

Molecular Plant-Microbe Interactions, 2007
The Arabidopsis mitogen-activated protein kinase (MAPK) kinase 2 (MKK2) was shown to mediate cold and salt stress responses through activation of the two MAP kinases MPK4 and MPK6.
Günter Brader, Armin Djamei, Markus Teige, E. Tapio Palva, Heribert Hirt   +4 more
doaj   +1 more source

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. [PDF]

, 2014
BackgroundConventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation.
Boyle, David L, Firestein, Gary S, Hammaker, Deepa, Topolewski, Katharyn   +3 more
core   +3 more sources

Function of MAP kinases in plant signal transduction pathway networks

浙江大学学报. 农业与生命科学版, 2004
Mitogen-activated protein kinase (MAPK) cascade, which consists of three Ser/Thr protein kinases, namely, MAP kinase kinase kinase, MAP kinase kinase and MAP kinase, is a universal module in signal transduction pathways in all eukaryotes.
SONG Dong-hui, SONG Feng-ming, ZHENG Zhong   +2 more
doaj   +1 more source

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

Insulin signaling inhibits the 5-HT_2C receptor in choroid plexus via MAP kinase

BMC Neuroscience, 2003
Background G protein-coupled receptors (GPCRs) interact with heterotrimeric GTP-binding proteins (G proteins) to modulate acute changes in intracellular messenger levels and ion channel activity.
Guan Kunliang, DePaoli-Roach Anna A, Marshall Mark S, Bye Leighan S, Zhang Shengwen, Hurley Joyce H, Fox Aaron P, Yu Lei   +7 more
doaj   +1 more source