Results 11 to 20 of about 518,432 (294)

Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase [PDF]

, 2006
ERK5 is a mitogen-activated protein (MAP) kinase regulated in human cells by diverse mitogens and stresses but also suspected of mediating the effects of a number of oncogenes.
King, Victoria, Millson, Stefan H, Mollapour, Medhi, Nuttall, James M, Pearl, Laurence H, Piper, Peter W, Prodromou, Chrisostomos, Truman, Andrew W   +7 more
core   +2 more sources

p38 Mitogen-Activated Protein Kinase Is Involved in Interleukin-6 Secretion from Human Ligamentum Flavum–Derived Cells Stimulated by Tumor Necrosis Factor-α [PDF]

Asian Spine Journal, 2021
Study Design Human ligamentum flavum–derived cells (HFCs) were obtained from surgical samples for a basic experimental study. Purpose We sought to evaluate the inflammatory response of human ligamentum flavum cells to investigate hypertrophic changes ...
Kiyoshi Yagi, Yuta Goto, Kenji Kato, Nobuyuki Suzuki, Akira Kondo, Yuya Waseda, Jun Mizutani, Yohei Kawaguchi, Yuji Joyo, Yuko Waguri-Nagaya, Hideki Murakami   +10 more
doaj   +1 more source

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP [PDF]

, 1999
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different cell types.
A Minden, A Sewing, AD Catling, B Hallberg, CJ Marshall, D Woods, DK Grandy, DK Morrison, DW Rose, F Schoentgen, Ferrell, J. E. Jr, Ferrell, J. E. Jr, H Mischak, HJ Schaeffer, JT Bruder, KL Guan, M Kortenjann, OV Gjorup, RM Lavbinsky, RM Tombes, S Häfner, S Li, SA Moodie, UR Rapp, W Kolch, W Kolch   +25 more
core   +1 more source

P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg. [PDF]

PLoS ONE, 2008
CD4+CD25+ regulatory T cells (Treg) are important mediators of immune tolerance. A subset of Treg can be generated in the periphery by TGF-beta dependent conversion of conventional CD4+CD25- T cells into induced Treg (iTreg).
Samuel Huber, Jörg Schrader, Gerhard Fritz, Katrin Presser, Steffen Schmitt, Ari Waisman, Stefan Lüth, Manfred Blessing, Johannes Herkel, Christoph Schramm   +9 more
doaj   +1 more source

P38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level [PDF]

, 1997
The cytokine tumor necrosis factor (TNF) alpha was found to stimulate the p38 mitogen activated protein (MAP) kinase signalling cascade in human umbilical vein endothelial cells.
Gaestel, M. (Matthias), Jong, N. (Netty) de, Koster, J.F. (Johan), Lee, J.C. (John), Pietersma, A. (Anna), Sluiter, W.J. (Wim), Tilly, B.C. (Bernard)   +6 more
core   +3 more sources

A human MAP kinase interactome. [PDF]

, 2010
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other ...
A Friedman, A Karydis, A Lunardi, AA Reszka, AC Gavin, AJ Whitmarsh, BP Kelley, C Widmann, Chih-yuan Chiang, Christopher H Martin, Cornelia Kurschner, D Wang, Diane L Barber, DJ LaCount, GD Bader, GL Johnson, J Kim, J Ptacek, JV Olsen, Jyoti Srivastava, K Hayashi, K Venkatesan, KC Gunsalus, L Chang, L Collin, M Baumgartner, M Karin, M Qi, M Rothe, Merril Gersten, Mike Smoot, P Uetz, PJ Cullen, R Hooley, R Konig, R Konig, R Konig, Russell Bell, S Peri, SA Johnson, SK Chanda, Sourav Bandyopadhyay, SP Denker, Sudhir Sahasrabudhe, Suhaila White, Sumit K Chanda, T Ito, T Reguly, Trey Ideker, W Kolch, W Kolch, Y Ho   +51 more
core   +3 more sources

CZK3, a MAP Kinase Kinase Kinase Homolog in Cercospora zeae-maydis, Regulates Cercosporin Biosynthesis, Fungal Development, and Pathogenesis

Molecular Plant-Microbe Interactions, 2003
The fungus Cercospora zeae-maydis causes gray leaf spot of maize and produces cercosporin, a photosensitizing perylenequinone with toxic activity against a broad spectrum of organisms.
Won-Bo Shim, Larry D. Dunkle
doaj   +1 more source

The NDR kinase scaffold HYM1/MO25 is essential for MAK2 map kinase signaling in Neurospora crassa. [PDF]

PLoS Genetics, 2012
Cell communication is essential for eukaryotic development, but our knowledge of molecules and mechanisms required for intercellular communication is fragmentary.
Anne Dettmann, Julia Illgen, Sabine März, Timo Schürg, Andre Fleissner, Stephan Seiler   +5 more
doaj   +1 more source

CRAF R391W is a melanoma driver oncogene. [PDF]

, 2016
Approximately 75% of melanomas have known driver oncogenic mutations in BRAF, NRAS, GNA11 or GNAQ, while the mutations providing constitutive oncogenic signaling in the remaining melanomas are not known.
Atefi, Mohammad, Avramis, Earl, Chmielowski, Bartosz, Friedman, Michael, Graeber, Thomas G, Lassen, Amanda, Le, Allison, Lomova, Anastasia, Ng, Charles, Ribas, Antoni, Titz, Bjoern, Tsoi, Jennifer   +11 more
core   +3 more sources

Oncogenic RET Kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans [PDF]

, 2014
To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry.
Airaksinen, Annabel Borg, Arighi, Artim, Chan, Chen, Chen, Chen, Coulpier, Cutillas, DiNitto, Endres, Furdui, Gibelin, Hubbard, Hubbard, Iván Plaza-Menacho, Judith Murray-Rust, Karin Barnouin, Kawamoto, Kerry Goodman, Knowles, Lew, Lougheed, McTigue, Mologni, Neil Q. McDonald, Phillip Knowles, Plaza Menacho, Plaza-Menacho, Plaza-Menacho, Plaza-Menacho, Plaza-Menacho, Rubén J. Martínez-Torres, Santoro, Stamos, Steen, Stephane Mouilleron, Wiesner, Yun, Zhang   +40 more
core   +1 more source