Results 191 to 200 of about 518,432 (294)

Structural basis for MEKK2 dimerization and substrate recognition. [PDF]

Nat Commun
Vish KJ, Huet-Calderwood C, Ha BH, Calderwood DA, Boggon TJ.   +4 more
europepmc   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Structural insights and biophysical characterization of p90RSK2:ERK2 complex. [PDF]

Biochem J
Kobori EK, Nguyen HPM, Wu J, Chen K, Malinovski R, Taylor S.   +5 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Molecular mechanism of PINK1 regulation by the Hsp90 machinery. [PDF]

Nat Commun
Tian X, Su J, Wang Z, Liu T, Xiong H, Sun S, Mei K, Sui SF.   +7 more
europepmc   +1 more source

Synthesis and biological activity of 2H-quinolizin-2-one based p38α MAP kinase inhibitors

, 2010
Robert M. Tynebor, Meng‐Hsin Chen, S. Natarajan, Edward A. O’Neill, James E. Thompson, Catherine E. Fitzgerald, Stephen J. O’Keefe, James B. Doherty   +7 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Fission Yeast MAP Kinase Is Required for the Increased Securin-Separase Interaction That Rescues Separase Mutants Under Stress [PDF]

, 2006
Yosuke Kawasaki, Koji Nagao, Takahiro Nakamura, Mitsuhiro Yanagida   +3 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

ZAK activation at the collided ribosome. [PDF]

Nature
Huso VL, Niu S, Catipovic MA, Saba JA, Denk T, Park E, Cheng J, Berninghausen O, Becker T, Green R, Beckmann R.   +10 more
europepmc   +1 more source