Results 211 to 220 of about 518,432 (294)

A map kinase pathway essential for mating and contributing to asexual development in Neurospora Crassa

, 2006
Dan Li
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2. [PDF]

Elife
Chen S, Basiashvili T, Hutchings J, Sanz Murillo M, Villagran Suarez A, Xiong E, Alegrio Louro J, Leschziner AE, Villa E.   +8 more
europepmc   +1 more source

The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin [PDF]

, 2006
Bardóczy, V., Bögre, L., Hatzimasoura, E., Helfer, A., Koncz, C., Magyar, Z., Mészáros, T., Peck, S., Rios, G., Serazetdinova, L., Teige, M.   +10 more
core  

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

<i>RGS4</i> in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression. [PDF]

World J Gastroenterol
Yang Y, Chen WM.
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Neurotrophin NGF/TrkA and BDNF/TrkB signaling orchestrates the immune microenvironment in osteosarcoma. [PDF]

Front Immunol
Liu H, Wang G, Wang C, Hou D, Li S, Fan Y, Liu B.   +6 more
europepmc   +1 more source

MAP kinase kinase kinase 12 (MAP3K12; DLK) [PDF]

, 2014

openalex   +1 more source

Networks of WRKY transcription factors in defense signaling [PDF]

, 2007
Eulgem, T., Somssich, I.
core   +2 more sources