Results 241 to 250 of about 518,432 (294)

The structural heterogeneity of AKT autoinhibition. [PDF]

Protein Sci
Xu L, Eren M, Weako J, Jang H, Keskin O, Gursoy A, Nussinov R.   +6 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Regulation of MAP kinase signaling cascade by microRNAs in Oryza sativa

, 2014
Raghuram Badmi, Arsheed H. Sheikh, Alok Sinha   +2 more
openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Polo-like kinase 1-inhibitor co-complex structures via the surface-entropy reduction approach and a DARPin-assisted approach. [PDF]

Acta Crystallogr D Struct Biol
Eberspaecher U, Schmitz AA, Siemeister G, Bömer U, Bandeiras TM, Matias PM, Schulze VK, Hillig RC.   +7 more
europepmc   +1 more source

A novel MAP kinase‐interacting protein MoSmi1 regulates development and pathogenicity in Magnaporthe oryzae [PDF]

Yu Wang, Xinyue Cui, Junlian Xiao, Xiaoru Kang, Jinmei Hu, Zhicheng Huang, Na Li, Chuyu Yang, Yuemin Pan, Shulin Zhang   +9 more
openalex   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Interplay Between Key Molecular Signaling Pathways and Immune Players Following Brain Irradiation. [PDF]

Mediators Inflamm
Richard SA.
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Inhibitors supercharge kinase turnover through native proteolytic circuits. [PDF]

Nature
Scholes NS, Bertoni M, Comajuncosa-Creus A, Kladnik K, Guo X, Frommelt F, Hinterndorfer M, Razumkov H, Prokofeva P, Schwalm MP, Born F, Roehm S, Imrichova H, Santini BL, Barone E, Schätz C, Muñoz I Ordoño M, Lechner S, Rukavina A, Serrano I, Abele M, Koren A, Kubicek S, Knapp S, Gray NS, Superti-Furga G, Kuster B, Shi Y, Aloy P, Winter GE.   +29 more
europepmc   +1 more source