Results 21 to 30 of about 518,432 (294)

MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation

Cell Division, 2007
Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade.
Rosner Marsha
doaj   +1 more source

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival [PDF]

, 2015
B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mature B cells. Earlier in vitro experiments with inhibitors that block MEK 1 and 2 suggested that activation of ERK 1 and 2 MAP ...
Jacque, E, Ley, SC, Schweighoffer, E, Tybulewicz, VL   +3 more
core   +1 more source

Molecular Cloning and Characterization of a Tobacco MAP Kinase Kinase That Interacts with SIPK

Molecular Plant-Microbe Interactions, 2000
A tobacco MAP kinase termed SIPK (salicylic acid-induced protein kinase) is activated in response to a variety of stress signals, including pathogen attack and wounding (S. Zhang and D. F. Klessig, Proc. Natl. Acad. Sci. USA 95:7225–7230, 1998; S.
Yanhong Liu, Shuqun Zhang, Daniel F. Klessig   +2 more
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Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain [PDF]

, 2013
We demonstrated a role for the Mg2 + transporter TRPM7, a bifunctional protein with channel and α-kinase domains, in aldosterone signaling. Molecular mechanisms underlying this are elusive.
Yogi, A., Callera, G.E., O'Connor, S., Antunes, T.T., Valinsky, W., Miquel, P., Montezano, A.C.I., Perraud, A.-L., Schmitz, C., Shrier, A., Touyz, R.M.   +10 more
core   +2 more sources

Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation

Cellular Physiology and Biochemistry, 2015
Background/Aims: Evidence in multiple tissues, including retina, suggests generation of reactive oxygen species (ROS) and the ensuing oxidative stress as triggers for mitochondrial defects and cell apoptosis.
Rajakrishnan Veluthakal, Binit Kumar, Ghulam Mohammad, Anjaneyulu Kowluru, Renu A. Kowluru   +4 more
doaj   +1 more source

Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination

eLife, 2016
Evolution has often copied and repurposed the mitogen-activated protein kinase (MAPK) signaling module. Understanding how connections form during evolution, in disease and across individuals requires knowledge of the basic tenets that govern kinase ...
Benjamin Groves, Arjun Khakhar, Cory M Nadel, Richard G Gardner, Georg Seelig   +4 more
doaj   +1 more source

Coordinated Regulation of Protoperithecium Development by MAP Kinases MAK-1 and MAK-2 in Neurospora crassa

Frontiers in Microbiology, 2021
Mitogen-activated protein (MAP) kinase pathways function as signaling hubs that are integral for many essential cellular processes, including sexual development.
Nan Lan, Nan Lan, Shuting Ye, Shuting Ye, Chengcheng Hu, Zhiling Chen, Jun Huang, Wei Xue, Wei Xue, Shaojie Li, Shaojie Li, Xianyun Sun, Xianyun Sun   +12 more
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Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
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Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: Effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity [PDF]

, 2006
Sub-lethal concentrations of the organophosphate phenyl saligenin phosphate (PSP) inhibited the outgrowth of axon-like processes in differentiating mouse N2a neuroblastoma cells (IC50 2.5 μM).
Abou-Donia, Abou-Donia, Alan J. Hargreaves, Barber, Barber, Brunet, Casida, Chambers, Denizot, Ehrich, El-Fawal, Eto, Flaskos, Flaskos, Forshaw, Fowler, Glynn, Glynn, Gupta, Hatch, Henschler, Ian C. Coutts, James, Jensen, John Flaskos, Johnson, Johnson, Johnson, Jortner, Jortner, Keilbaugh, Laemmli, Lee, Li, Lowry, Magdalini Sachana, Mary Bountouri, Maxine J. Fowler, Nixon, Nomeir, Nomeir, Nostrandt, Nostrandt, Paul Glynn, Perron, Rosenstock, Schmuck, Sharma, Song, Suwita, Towbin, Van Teinhoven, Veeranna, Veronesi, W. Graham McLean, Wayne Harris, Zhao   +56 more
core   +1 more source

Mitogen-Activated Protein Kinase Cascades in Plant Hormone Signaling

Frontiers in Plant Science, 2018
Mitogen-activated protein kinase (MAPK) modules play key roles in the transduction of environmental and developmental signals through phosphorylation of downstream signaling targets, including other kinases, enzymes, cytoskeletal proteins or ...
Przemysław Jagodzik, Małgorzata Tajdel-Zielinska, Agata Ciesla, Małgorzata Marczak, Agnieszka Ludwikow   +4 more
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