Results 31 to 40 of about 518,432 (294)

HAM-5 functions as a MAP kinase scaffold during cell fusion in Neurospora crassa. [PDF]

, 2014
Cell fusion in genetically identical Neurospora crassa germlings and in hyphae is a highly regulated process involving the activation of a conserved MAP kinase cascade that includes NRC-1, MEK-2 and MAK-2. During chemotrophic growth in germlings, the MAP
Ansong, C, Camp, DG, Glass, NL, Jonkers, W, Leeder, AC, Smith, RD, Starr, TL, Wang, Y, Yang, F   +8 more
core   +8 more sources

Positive feedback induces switch between distributive and processive phosphorylation of Hog1

Nature Communications, 2023
Cellular decision making often builds on ultrasensitive MAPK pathways. The phosphorylation mechanism of MAP kinase has so far been described as either distributive or processive, with distributive mechanisms generating ultrasensitivity in theoretical ...
Maximilian Mosbacher, Sung Sik Lee, Gilad Yaakov, Mariona Nadal-Ribelles, Eulàlia de Nadal, Frank van Drogen, Francesc Posas, Matthias Peter, Manfred Claassen   +8 more
doaj   +1 more source

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

Calcineurin Contributes to the Enhancing Effect of Adenosine on Nerve Growth Factor-Induced Neurite Outgrowth via the Decreased Duration of p38 Mitogen-Activated Protein Kinase Phosphorylation

Journal of Pharmacological Sciences, 2004
Adenosine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. We found that adenosine increases NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK), but decreases the duration of phosphorylation of p38 ...
Yoshikage Muroi, Toshiaki Ishii, Kentarou Teramoto, Masatoshi Hori, Masakazu Nishimura   +4 more
doaj   +1 more source

Activation of the Erk8 Mitogen-activated Protein (MAP) Kinase by RET/PTC3, a Constitutively Active Form of the RET Proto-oncogene [PDF]

, 2006
Mitogen-activated protein (MAP) kinases have a central role in several biological functions, including cell adhesion and spreading, chemotaxis, cell cycle progression, differentiation, and apoptosis.
Acunzo, Mario, Carlomagno, Francesca, Carlomagno, Maria Stella, Catania, Annunziata, Chiariello, Mario, Iavarone, Carlo, Melillo, Rosa Marina, Santoro, Massimo   +7 more
core   +2 more sources

BWMK1, a Novel MAP Kinase Induced by Fungal Infection and Mechanical Wounding in Rice

Molecular Plant-Microbe Interactions, 1999
The activation of the mitogen-activated protein (MAP) kinases by different environmental stresses has been previously observed in several dicot plant species. Here, we report the isolation of a novel MAP kinase in rice that is induced during infection by
Chaozu He, Steven Haw Tien Fong, Daichang Yang, Guo-Liang Wang   +3 more
doaj   +1 more source

EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity. [PDF]

PLoS Genetics, 2014
Mitogen-activated protein (MAP) kinase signaling cascades play important roles in the regulation of plant defense. The Raf-like MAP kinase kinase kinase (MAPKKK) EDR1 negatively regulates plant defense responses and cell death.
Chunzhao Zhao, Haozhen Nie, Qiujing Shen, Shuqun Zhang, Wolfgang Lukowitz, Dingzhong Tang   +5 more
doaj   +1 more source

p38 MAP kinase mediated proteoglycan synthesis as a target for the prevention of atherosclerosis [PDF]

, 2008
The major underlying pathology of most cardiovascular disease is the chronic inflammatory disease of atherosclerosis. Type 2 diabetes, also recognised as an inflammatory condition, accelerates the development of atherosclerosis.
Ballinger, M, Burch, M, Dadlani, H, Getachew, R, Little, P, Osman, N   +5 more
core   +1 more source

The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. [PDF]

, 2018
Smk1 is a meiosis-specific MAP kinase (MAPK) in budding yeast that is required for spore formation. It is localized to prospore membranes (PSMs), the structures that engulf haploid cells during meiosis II (MII).
Diamond, Aviva, Neiman, Aaron M., Omerza, Gregory, Philips, Timothy, Tio, Chong Wai, Winter, Edward   +5 more
core   +3 more sources

Structural and functional basis for p38-MK2 activated Rsk signalling in Toll-Like receptor-stimulated dendritic cells [PDF]

, 2015
Rsk kinases play important roles in several cellular processes such as proliferation, metabolism, and migration. Until recently, Rsk activation was thought to be exclusively initiated by Erk1/2, but in dendritic cells (DC) Rsk is also activated by p38 ...
Edgar, Alexander J., Hanauer, André, Watts, Colin, Zaru, Rossana   +3 more
core   +2 more sources