Results 41 to 50 of about 518,432 (294)

(-)-Epigallocatechin Gallate Reduces Platelet-Derived Growth Factor-BB-Stimulated Interleukin-6 Synthesis in Osteoblasts: Suppression of SAPK/JNK

Mediators of Inflammation, 2008
We previously showed that the mitogen-activated protein (MAP) kinase superfamily, p44/p42 MAP kinase, p38 MAP kinase, and stress-activated protein kinase (SAPK)/c-Jun N-terminal (JNK), positively plays a part in the platelet-derived growth factor-BB ...
Shinji Takai, Rie Matsushima-Nishiwaki, Seiji Adachi, Hideo Natsume, Chiho Minamitani, Jun Mizutani, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa   +8 more
doaj   +1 more source

Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors.

PLoS Computational Biology, 2010
In order to fully understand protein kinase networks, new methods are needed to identify regulators and substrates of kinases, especially for weakly expressed proteins.
Thomas C Whisenant, David T Ho, Ryan W Benz, Jeffrey S Rogers, Robyn M Kaake, Elizabeth A Gordon, Lan Huang, Pierre Baldi, Lee Bardwell   +8 more
doaj   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]

PLoS ONE, 2013
Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda, Kunihiro Fukushima, Ryotaro Omichi, Shin Kariya, Kazunori Nishizaki   +4 more
doaj   +1 more source

Identification and characterization of CKLiK, a novel granulocyteCa^(++)/calmodulin-dependent kinase [PDF]

, 2000
Human granulocytes are characterized by a variety of specific effector functions involved in host defense. Several widely expressed protein kinases have been implicated in the regulation of these effector functions.
Anderson, Arcaro, Baltus, Burgering, Caldenhoven, Chin, Coffer, Coffer, Coffer, Cross, Dang, Davies, De Cesare, De Groot, De Groot, DeLeo, Downey, Elferink, Enslen, Figdor, Goldberg, Green, Greenberger, Hanks, Hanson, Haslett, Haslett, Hii, Jan-Willem J. Lammers, Jensen, Kitani, Klippel, Koenderman, Kozak, Kwiatkowska, Lali, Lawson, Lee, Leo Koenderman, Littlewood, Mandeville, Mitsuyama, Morgenstern, Mócsai, Nairn, Nairn, Okada, Paul J. Coffer, Sanchez, Sandra Verploegen, Savill, Scheid, Schulman, Segal, Selbert, Sheng, Siddiqui, Soderling, Tokumitsu, van Dijk, Vlahos, Watanabe, Yano, Zauli   +63 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The BMP1 Gene Is Essential for Pathogenicity in the Gray Mold Fungus Botrytis cinerea

Molecular Plant-Microbe Interactions, 2000
In Magnaporthe grisea, a well-conserved mitogen-activated protein (MAP) kinase gene, PMK1, is essential for fungal pathogenesis. In this study, we tested whether the same MAP kinase is essential for plant infection in the gray mold fungus Botrytis ...
Li Zheng, Mathew Campbell, Jennifer Murphy, Stephen Lam, Jin-Rong Xu   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The MAP Kinase Kinase Gene AbSte7 Regulates Multiple Aspects of Alternaria brassicicola Pathogenesis

The Plant Pathology Journal, 2019
Mitogen-activated protein kinase (MAPK) cascades in fungi are ubiquitously conserved signaling pathways that regulate stress responses, vegetative growth, pathogenicity, and many other developmental processes. Previously, we reported that the AbSte7 gene,
Kai Lu, Min Zhang, Ran Yang, Min Zhang, Qinjun Guo, Kwang-Hyun Baek, Houjuan Xu   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source