Results 51 to 60 of about 518,432 (294)

Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation.

PLoS Biology, 2012
Local mRNA translation in neurons has been mostly studied during axon guidance and synapse formation but not during initial neurite outgrowth. We performed a genome-wide screen for neurite-enriched mRNAs and identified an mRNA that encodes mitogen ...
Daniel Feltrin, Ludovico Fusco, Harald Witte, Francesca Moretti, Katrin Martin, Michel Letzelter, Erika Fluri, Peter Scheiffele, Olivier Pertz   +8 more
doaj   +1 more source

MAP kinases differentially bind and phosphorylate NOS3 via two unique NOS3 sites

FEBS Open Bio, 2022
Nitric oxide synthase 3 (NOS3) is a major vasoprotective enzyme that catalyzes the conversion of l‐arginine to nitric oxide (NO) in response to a significant number of signaling pathways.
Xzaviar K. V. Solone, Amber L. Caldara, Brady Wells, Hao Qiao, Lydia R. Wade, John C. Salerno, Katy A. Helms, Katherine E. R. Smith, Jonathan L. McMurry, Carol A. Chrestensen   +9 more
doaj   +1 more source

Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]

, 2006
BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
Albani, Salvatore, Boyle, David L, Firestein, Gary S, Hammaker, Deepa, Jones, Toni L, Rosengren, Sanna, Sorkin, Linda, Svensson, Camille I   +7 more
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Role of ether-linked lysophosphatidic acids in ovarian cancer cells

Journal of Lipid Research, 2002
Naturally occurring alkyl- and alkenyl-lysophosphatidic acids (al-LPAs) are detected and elevated in ovarian cancer ascites compared with ascites from non-malignant diseases.
Jun Lu, Yi-jin Xiao, Linnea M. Baudhuin, Guiying Hong, Yan Xu   +4 more
doaj   +1 more source

Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila [PDF]

, 2012
The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branched network of air-filled tubes. Its developmental logic is similar in some ways to that of the vertebrate vascular system.
Jeon, Mili, Scott, Matthew P., Zinn, Kai
core   +3 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Nardosinone Enhances Nerve Growth Factor-Induced Neurite Outgrowth in a Mitogen-Activated Protein Kinase- and Protein Kinase C-Dependent Manner in PC12D Cells

Journal of Pharmacological Sciences, 2003
: The mechanism to enhance nerve growth factor (NGF, 2 ng/ml)-induced neurite outgrowth from PC12D cells by nardosinone isolated from Nardostachys chinensis was examined.
Ping Li, Tohru Yamakuni, Kimihiro Matsunaga, Shunzo Kondo, Yasushi Ohizumi   +4 more
doaj   +1 more source

MAP kinase phosphatase 2 regulates macrophage-adipocyte interaction. [PDF]

PLoS ONE, 2015
Inflammation is critical for the development of obesity-associated metabolic disorders. This study aims to investigate the role of mitogen-activated protein kinase phosphatase 2 (MKP-2) in inflammation during macrophage-adipocyte interaction.White ...
Huipeng Jiao, Peng Tang, Yongliang Zhang
doaj   +1 more source

Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

Cell Reports: Methods, 2021
Summary: A primary goal of the US National Cancer Institute's Ras initiative at the Frederick National Laboratory for Cancer Research is to develop methods to quantify RAS signaling to facilitate development of novel cancer therapeutics.
Jeffrey R. Whiteaker, Kanika Sharma, Melissa A. Hoffman, Eric Kuhn, Lei Zhao, Alexandra R. Cocco, Regine M. Schoenherr, Jacob J. Kennedy, Ulianna Voytovich, Chenwei Lin, Bin Fang, Kiah Bowers, Gordon Whiteley, Simona Colantonio, William Bocik, Rhonda Roberts, Tara Hiltke, Emily Boja, Henry Rodriguez, Frank McCormick, Matthew Holderfield, Steven A. Carr, John M. Koomen, Amanda G. Paulovich   +23 more
doaj   +1 more source