Results 231 to 240 of about 328,504 (254)

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Signaling pathways in systemic lupus erythematosus and therapeutic implications. [PDF]

Front Immunol
Balogh L, Kovács VG, Nagy G, Németh T.
europepmc   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

VEGF Signaling Pathway Germline Polymorphisms as Prognostic Pharmacogenetic Biomarkers in Localized High-Grade Osteosarcoma Patients from the GEIS-33 Protocol. [PDF]

Pharmaceuticals (Basel)
Salazar J, Arranz MJ, Martin-Broto J, Serra M, Palmerini E, Martínez-García J, Juan-Ribelles A, Andion M, Martinez-Trufero J, Gutiérrez G, Echebarria-Barona A, Vaz-Salgado MA, Regueiro A, Alvarez R, Valverde C, Luna P, Blay P, Sebio A.   +17 more
europepmc   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Non-Catalytic Inhibitors of the p38/MK2 Interface: Repurposing Approved Drugs to Target Neuroinflammation in Alzheimer's Disease. [PDF]

J Med Chem
Hu M, Li A, Fleming P, Gralla J, Negrón Terón K, Zhou Y, Miller EJ, Beyett TS, Wen Z, Du Y, Fu H, Ivanov AA.   +11 more
europepmc   +1 more source

<i>Agrobacterium fabrum</i> (<i>tumefaciens</i>) Chemosensory System: A Typical Model of One Histidine Kinase for Two Coupling Proteins and Multiple Response Regulators. [PDF]

Microorganisms
Liu J, Feng M, Xu N, Wang H, Guo M.
europepmc   +1 more source

Molecular mechanisms of acute inflammation: systemic responses and kidney-specific pathophysiology. [PDF]

Function (Oxf)
Chelangarimiyandoab F, Lavoie JC, Flamand N, Cordat E, Breton S.   +4 more
europepmc   +1 more source

Toll-like receptors and their role in the pathogenesis of myasthenia gravis: a comprehensive review. [PDF]

Front Immunol
Zheng X, Li L, Ma H, Zhu M, Li X, Feng X.   +5 more
europepmc   +1 more source