Results 241 to 250 of about 328,504 (254)

Protein swarm-based cause-effect analysis: effects of microRNAs on cooperation networks linking COVID-19 infections, atherosclerosis, and Alzheimer's disease. [PDF]

Front Cardiovasc Med
Fliri A, Sostek R, Kajiji S.
europepmc   +1 more source

Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome

Bayer FP, Müller J, Kabella N, Abele M, Chang Y, Estrada Duenas LD, Jensen C, Hamood F, Lee C, Schneider A, The M, Kuster B.   +11 more
europepmc   +1 more source

The mitogen-activated protein kinases system (MAP kinase cascade): its role in skin signal transduction. A review

Journal of Dermatological Science, 1996
Mitogen-activated protein (MAP) kinases are proline-directed kinases which are downstream components of a pathway involving p21ras and the serine/threonine kinase Raf-1. They represent an important link between the signal transduction processes at the level of the plasma membrane and the final nuclear events.
Christoph C. Geilen, Marcus Wieprecht, Constantin E. Orfanos   +2 more
openalex   +3 more sources

Methods to Study MAP Kinase Signalling in the Central Nervous System

, 2010
The mitogen-activated protein kinase (MAPK) family of intracellular signal transducers includes ERK1/2, ERK5, JNK/SAPK, and p38 and has been shown to control survival, proliferation and differentiation of cells composing the central and peripheral nervous system.
Bettina Wagner, Maria Sibilia
openalex   +3 more sources

Tumor Evasion of the Immune System: Inhibiting p38 MAP Kinase Signaling Restores the Function of Dendritic Cells.

Blood, 2005
Abstract Dendritic cells (DCs) from cancer patients are functionally defective, however, molecular mechanisms underlying are still poorly understood. In this study, we used the murine 5TGM1 myeloma model to examine the effect and mechanism of tumor-derived factors on the differentiation and function of DCs. Myeloma cells (5TGM1) or tumor
Qing Yi, Siqing Wang, Jing Yang, Jianfei Wang, Michele Wezeman, Larry W. Kwak   +5 more
openalex   +2 more sources

THE ROLE OF THEhsp90-BASED CHAPERONE SYSTEM IN SIGNAL TRANSDUCTION BY NUCLEAR RECEPTORS AND RECEPTORS SIGNALING VIA MAP KINASE

Annual Review of Pharmacology and Toxicology, 1997
▪ Abstract  The multicomponent heat-shock protein (hsp) 90–based chaperone system is an ubiquitous protein-folding system in the cytoplasm of eukaryotes. Several signal transduction systems utilize an interaction with hsp90 as an essential component of the signaling pathway.
William B. Pratt
openalex   +3 more sources

The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions

, 2010
Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK) cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four MAPK cascades have been identified in the last 20 years and those are usually named according to the MAPK components that are the central building blocks of each of the ...
Yonat Keshet, Rony Seger
openalex   +3 more sources

Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney

International Journal of Pharmaceutics, 2016
The in vivo impact of two generation 6 cationic polyamidoamine (PAMAM) dendrimers on cellular signaling via extracellular-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38 MAPK), as well as their relationship to epidermal growth factor receptor (EGFR), were studied in the normal and/or diabetic rat kidney. A single 10mg/kg/i.p
Saghir Akhtar, Bashayer Al-Zaid, Ahmed Z. El‐Hashim, Bindu Chandrasekhar, Sreeja Attur, Ibrahim F. Benter   +5 more
openalex   +3 more sources