Zhongguo shiyan zhenduanxue目的 运用网络药理学技术结合细胞及动物实验探讨梅花草提取物抑制脑胶质瘤恶性增殖的作用机制。方法 通过中药系统药理学分析平台(TCMSP)数据库筛选梅花草的有效化合物，使用OMIM、Genecards、Pubchem等数据库预测梅花草有效化合物对脑胶质瘤的潜在作用靶点，应用Cytoscape 3.9.1和STRING 11.5数据库构建化合物-靶点网络、蛋白质互作(PPI),筛选出核心基因，运用DAVID 6.8数据库对靶点进行基因本体(GO)的富集分析和京都基因与基因组百科全书(KEGG)的通路富集分析，
王睿君 +3 more
doaj
[IOX1 alleviates hepatic ischemia-reperfusion injury by inhibiting mitogen-activated protein kinase signaling pathway]. [PDF]
Zhonghua Gan Zang Bing Za ZhiHu SC +7 more
europepmc +1 more source
, 2007 为了鉴定柱状黄杆菌(Flavobacterium columnare)的毒力相关因子,利用蛋白质组学方法分析了强毒株G4R3和弱毒株G18的外膜蛋白。双向电泳结合图像分析,共发现了8个差异表达的蛋白点。经过胶内酶解和质谱分析,其中的1个蛋白点被鉴定为LemA蛋白 ...
聂品, 刘国勇, 陈发菊
core
, 1995 于1988年7月—8月和1989年7月—8月，以酪蛋白为蛋白源，采用蛋白含量梯度法进行黑鲷饲料中最适蛋白质含量研究。结果表明，黑鲷幼鱼饲料中，蛋白质的最适含量约为50．19％。1988年8月—9月和1989年8月—9月，以玉筋鱼为动物蛋白源，以花生饼粉为植物蛋白源，饲料中总蛋白质含量相等，进行黑鲷饲料中最适动、植物蛋白比研究。结果表明，黑鲷幼鱼饲料中，动、植物蛋白的最适比例为1.00：0.89－0 ...
刘镜恪,王可玲,王新成,刘建康
core
[CAMK2a Regulates Paclitaxel Resistance in Oral Squamous Cell Carcinoma Cells by Activating the ERK Signaling Pathway]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanWang J +5 more
europepmc +1 more source
[Research Advances in the Pulmonary Carcinogenic Effects of Atmospheric Fine Particulate Matter Mediated by GPER]. [PDF]
Zhongguo Fei Ai Za ZhiLi Z, Li D.
europepmc +1 more source
[DOT1L controls neuronal amyloid precursor protein expres-sion via the p38 MAPK-mediated mitochondrial dynamics homeostasis axis]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanZhang Y +6 more
europepmc +1 more source
[Natural bear bile powder attenuates lipopolysaccharide-induced acute lung injury in mice by regulating the NF-κB and Nrf-2/HO-1 signaling pathways]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoSun Y, Lu X, Zhang X, Guo J, Jin X.
europepmc +1 more source
[<i>Jianwei Shoutai</i> Pill reduces spontaneous abortion in mice by inhibiting Exo-miR-410-3p uptake and promoting trophoblast epithelial-mesenchymal transition, migration, and invasion]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoXu Z, Chen Z, Xie L, Li X, Qin G, Gao J.
europepmc +1 more source
[Screening of potential bioactive constituents in wall-broken <i>Ganoderma lucidum</i> spore powder for promoting ulcer healing]. [PDF]
Hua Xi Kou Qiang Yi Xue Za ZhiLiu J, Wang J, Li Y, Cong Y, Guan X.
europepmc +1 more source