Results 261 to 270 of about 449,479 (345)

Small protein DDX11-AS1-ORF encoded by lncRNA DDX11-AS1 promotes colorectal cancer progression through VEGFA-activated p38-MAPK pathway. [PDF]

Am J Cancer Res
Cheng Y, Dong J, Shang K, Zhang L, Chen Y, Li R, Li Z, Zhang Z, Wang Y.   +8 more
europepmc   +1 more source

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats

Advanced Science, EarlyView.
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai, Xuan Lu, Xu Yan, Han Su, Yuejun Lin, Zhaowei Jiang, Zhixian Zong, Haixing Wang, Leo Yik Chun Yan, Xiaoting Zhang, Ming Wang, Zhengmeng Yang, Jiakang Jin, Yaofeng Wang, Wayne Yuk‐Wai Lee, Xiaohua Jiang, Ho Ko, Lu Feng, Micky D. Tortorella, Sien Lin, Gang Li   +20 more
wiley   +1 more source

Immunoenhancement Function of the Novel Hexapeptide (LVVLGH) from Thick-Shelled Mussel (<i>Mytilus coruscus</i>) on Immunodeficient Mice by Activating the NF-κB/MAPK Pathway. [PDF]

Foods
Yang X, Zeng Y, Que F, Fu S, Xu L, Yu F, Wang B.   +6 more
europepmc   +1 more source

Chirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway

Advanced Science, EarlyView.
Chirality governs the limbal epithelial stem cell fate. Right‐handed chirality enhances cell proliferation and differentiation, while left‐handed chirality partially maintains cell stemness. By activating the Notch pathway, 3D right‐handed chiral hydrogel offers a drug‐free and cell‐free strategy for effective corneal regeneration.
Shiding Li, Yu Zhao, Junzhao Chen, Beibei Wu, Nianxuan Wu, Hao Sun, Liangbo Chen, Chuanliang Feng, Yao Fu   +8 more
wiley   +1 more source

Neuronal p38 MAPK Signaling Contributes to Cisplatin-Induced Peripheral Neuropathy. [PDF]

Antioxidants (Basel)
Goel Y, Argueta DA, Peterson K, Lomeli N, Bota DA, Gupta K.   +5 more
europepmc   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer

Nature Network Boston, 2015
G. Hrustanovic, V. Olivas, E. Pazarentzos, Asmin Tulpule, S. Asthana, C. Blakely, R. Okimoto, Luping Lin, Dana S. Neel, A. Sabnis, Jennifer Flanagan, Elton Chan, M. Varella-Garcia, D. Aisner, A. Vaishnavi, S. Ou, E. Collisson, E. Ichihara, P. Mack, C. Lovly, N. Karachaliou, R. Rosell, J. Riess, R. Doebele, T. Bivona   +24 more
semanticscholar   +1 more source

SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8⁺ T cells via the MAPK pathway. [PDF]

Front Immunol
Chen B, Zhu L, Lin X, Kwan KJS, Wang J, Lu Y, Li J, Deng Y, Jiang S, Tang J, Yu B.   +10 more
europepmc   +1 more source

A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic Leukemia

Advanced Science, EarlyView.
A self‐assembling nanotherapeutic strategy is designed—CD38‐PHD/G‐NPs, which released γ‐secretase inhibitor first, followed by adaptive dihydroartemisnin release in response to elevated reactive oxygen species levels. This controlled, sequential release strategy maximizes the synergistic anti‐leukemic efficacy of two agents with distinct mechanisms of ...
Ruinan Jia, Yang Liu, Jilong Xiao, Yuan Xia, Xin Zhao, Huixian Ma, Jingjing Ye, Zhiyue Zhang, Tao Sun, Chunyan Ji   +9 more
wiley   +1 more source

Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation. [PDF]

J Immunother Cancer
Zhu W, Lu S, Jia L, Liu B, Song S, Bao X, Yu T, Zhang Y, Miao Z, He J.   +9 more
europepmc   +1 more source