Results 271 to 280 of about 449,479 (345)

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

Proceedings of the National Academy of Sciences of the United States of America, 2015
Xiaolin Nan, Tanja M Tamgüney, E. Collisson, Li-jung Lin, C. Pitt, Jacqueline Galeas, Sophia Lewis, J. Gray, F. McCormick, S. Chu   +9 more
semanticscholar   +1 more source

PRDX1 knockdown promotes erastin-induced ferroptosis and impedes diffuse large B-cell lymphoma development by inhibiting the MAPK/ERK pathway. [PDF]

BMC Cancer
Lin C, Xie S, Wang M, Shen J.
europepmc   +1 more source

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source

Targeting the MAPK signaling pathway: implications and prospects of flavonoids in 3P medicine as modulators of cancer cell plasticity and therapeutic resistance in breast cancer patients. [PDF]

EPMA J
Kubatka P, Bojkova B, Nosalova N, Huniadi M, Samuel SM, Sreenesh B, Hrklova G, Kajo K, Hornak S, Cizkova D, Bubnov R, Smokovski I, Büsselberg D, Golubnitschaja O.   +13 more
europepmc   +1 more source

Antiproliferative Effects of Trapidil in Vascular Smooth Muscle Cells are Associated by Inhibition of MAPK and P34cdc2 Activity

, 2000
Yan Cheng, Ping Liu, Hui Chen, Fandian Zeng   +3 more
openalex   +1 more source

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Advanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang, Xiaojun Zhang, Xupeng Yang, Xingshi Chen, Yuehong Wang, Jingying Hu, Rui Liu, Xiaoying Luo   +7 more
wiley   +1 more source

The Role of the MAPK Signaling Pathway in Cardiovascular Disease: Pathophysiological Mechanisms and Clinical Therapy. [PDF]

Int J Mol Sci
Wang X, Liu R, Liu D.
europepmc   +1 more source

A Study of Skeletal Stem Cell Dynamics and Its Potential Applications in the Design of a Titanium Implant for Senile Osteoporosis

Advanced Science, EarlyView.
Senescent mesenchymal stromal cells (MSCs) drive age‐related osteoporosis (A‐OP) via adipogenic bias. Resveratrol, selected from transcriptome‐identified core genes, is delivered locally using GelMA‐chitosan hydrogel‐functionalised titanium implants. In A‐OP microenvironments, the hydrogel enables the sustained release of resveratrol, which reverses ...
Wuzhe Fan, Tao Zheng, Mingsong Mao, Pengfei Gao, Yulu Yang, Rong Wang, Yao Yang, Yangpeng Zuo, Tiantian Yuan, Ruqing Bai, Weihu Yang, Xingchen Yan, Kaiyong Cai   +12 more
wiley   +1 more source

Eosinophilic gastroenteritis in a 14-year-old patient with Noonan syndrome with a PTPN11 variation: a case report. [PDF]

J Med Case Rep
Koga N, Yatsuga S, Kubota K, Niimi T, Inoue T, Nagamitsu S.   +5 more
europepmc   +1 more source