Results 291 to 300 of about 736,655 (384)

Inhibition of the JAK and MEK Pathways Limits Mitochondrial ROS Production in Human Saphenous Vein Smooth Muscle Cells. [PDF]

Cells
Bolanle IO, Hobkirk JP, Loubani M, Sturmey RG, Palmer TM.   +4 more
europepmc   +1 more source

Bone marrow mesenchymal stem cells repair Cr (VI)- injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway

, 2019
Fei Yin, Jun Yan, Yue Zhao, Ke-Jun Guo, Zhili Zhang, Anpei Li, Chunyang Meng, Li Guo   +7 more
openalex   +1 more source

Reprogramming the Myocardial Infarction Conductive Microenvironment with Superconductive Ionic Patch for Cardiac Function Repair

Advanced Science, EarlyView.
A super‐conductive ionic patch reprograms the post‐infarction microenvironment by enabling stable ionic migration and electrical signal transmission within damaged myocardium. The patch rapidly adheres to cardiac tissue, enhances conduction velocity, suppresses excitation‐contraction decoupling, and promotes structural and functional cardiac repair in ...
Changyong Wang, Zhuang Zhang, Qi Yin, Changgeng Xu, Linlin Liang, Siwei Li, Yuwei Zhao, Chunlan Wang, Jin Zhou   +8 more
wiley   +1 more source

<i>CSRNP1</i> Promotes Apoptosis and Mitochondrial Dysfunction via ROS-Mediated JNK/p38 MAPK Pathway Activation in Hepatocellular Carcinoma. [PDF]

Oncol Res
Shi H, Chen L, Huang J, Lin X, Huang L, Tang M, Lu K, Wang W, Zhu M.   +8 more
europepmc   +1 more source

Tiotropium bromide inhibits TGF-&szlig;-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro

, 2010
Kazuhito Asano
openalex   +2 more sources

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Multi-Level Profiling of MAPK-Associated Genes and MicroRNAs Uncovers Regulatory Networks in Breast Cancer Subtypes. [PDF]

Int J Mol Sci
Król-Jatręga K, Mitka-Krysiak E, Boroń K, Ossowski P, Zmarzły N, Ordon P, Kulej W, Sirek T, Sirek A, Boroń D, Wyrobiec G, Prudnikov Y, Grabarek BO.   +12 more
europepmc   +1 more source

Loss of MAPK Pathway Activation in Post-Mitotic Retinal Cells as Mechanism in MEK Inhibition-Related Retinopathy in Cancer Patients

, 2016
Elon H. C. van Dijk, Danique E. M. Duits, Mieke Versluis, Gregrorius P. M. Luyten, Arthur A. Bergen, Ellen Kapiteijn, Mark J. de Lange, Camiel J. F. Boon, Pieter A. van der Velden   +8 more
openalex   +1 more source

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

Nature Genetics, 2015
T. F. Eleveld, D. Oldridge, V. Bernard, J. Koster, L. C. Daage, S. Diskin, L. Schild, Nadia Bentahar, Angela Bellini, Mathieu Chicard, E. Lapouble, V. Combaret, Patricia Legoix-né, J. Michon, T. Pugh, Lori S. Hart, J. Rader, E. Attiyeh, Jun S. Wei, Shile Zhang, A. Naranjo, J. Gastier-Foster, M. Hogarty, S. Asgharzadeh, Malcolm A. Smith, Jaime M Guidry Auvil, T. Watkins, Danny A Zwijnenburg, M. E. Ebus, P. V. van Sluis, Anne Hakkert, Esther M. van Wezel, C. E. van der Schoot, E. M. Westerhout, J. Schulte, G. Tytgat, M. Dolman, I. Janoueix-Lerosey, D. Gerhard, H. Caron, O. Delattre, J. Khan, R. Versteeg, G. Schleiermacher, J. Molenaar, J. Maris   +45 more
semanticscholar   +1 more source

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source