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Compartmentalised MAPK Pathways
2008The mitogen-activated protein kinase (MAPK) pathway provides cells with the means to interpret external signal cues or conditions, and respond accordingly. This cascade regulates many cell functions such as differentiation, proliferation and migration.
David B. Sacks, Michael D. Brown
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Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.
Physiological Reviews, 2012The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs) were first elucidated in 1994, and by 2001, substantial progress had been made in identifying the architecture of the pathways upstream of these kinases as well as in ...
J. Kyriakis, J. Avruch
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Current Opinion in Oncology, 2008
As understanding of molecular and genetic processes in cancer evolves, so does appreciation of tumor heterogeneity. Tumor profiling has expanded knowledge of relevant pathways, and their interplay. Similar to the revolution in breast cancer with the discovery and successful therapeutic targeting of HER2/neu, the melanoma field is rapidly evolving.
Keith T. Flaherty +2 more
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As understanding of molecular and genetic processes in cancer evolves, so does appreciation of tumor heterogeneity. Tumor profiling has expanded knowledge of relevant pathways, and their interplay. Similar to the revolution in breast cancer with the discovery and successful therapeutic targeting of HER2/neu, the melanoma field is rapidly evolving.
Keith T. Flaherty +2 more
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American Journal of Physiology-Renal Physiology, 2000
Following an overview of the biochemistry of mitogen-activated protein kinase (MAPK) pathways, the relevance of these signaling events to specific models of renal cell function and pathophysiology, both in vitro and in vivo, will be emphasized. In in vitro model systems, events activating the principal MAPK families [extracellular signal-regulated and ...
Zheng Zhang, David M. Cohen, Wei Tian
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Following an overview of the biochemistry of mitogen-activated protein kinase (MAPK) pathways, the relevance of these signaling events to specific models of renal cell function and pathophysiology, both in vitro and in vivo, will be emphasized. In in vitro model systems, events activating the principal MAPK families [extracellular signal-regulated and ...
Zheng Zhang, David M. Cohen, Wei Tian
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ACS Chemical Biology, 2011
The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
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The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
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MAPK cascades in plant disease resistance signaling.
Annual Review of Phytopathology, 2013Mitogen-activated protein kinase (MAPK) cascades are highly conserved signaling modules downstream of receptors/sensors that transduce extracellular stimuli into intracellular responses in eukaryotes.
Xiangzong Meng, Shuqun Zhang
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MAPKs: new targets for neurodegeneration
Expert Opinion on Therapeutic Targets, 2003Neurodegenerative diseases remain a huge unmet pharmaceutical need. For some diseases such as Parkinson's disease, there are currently only palliative therapies, and for others such as Alzheimer's disease there are no proven therapies on the market that have any significant impact on disease progression.
Neil Wilkie, Sarah J. Harper
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Advancements in MAPK signaling pathways and MAPK‐targeted therapies for ameloblastoma: A review
Journal of Oral Pathology & Medicine, 2019Numerous signal transduction pathways are closely associated with the occurrence, development, and prognosis of ameloblastoma (AM). Mitogen-activated protein kinase (MAPK) is a serine/threonine-specific protein kinase that transduces intracellular ...
Z. You +4 more
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Inhibition of MAPK Pathway by a Synthetic Peptide Corresponding to the Activation Segment of MAPK
Biochemical and Biophysical Research Communications, 1998Mitogen-activated protein kinase (MAPK) is activated by phosphorylation within its activation segment. Upon phosphorylation, the activation segment refolds to provide the active conformation of the enzyme. We reported previously that a phosphorylation-sensitive secondary structure could be formed in a 26-amino-acid long synthetic peptide corresponding ...
Kumiko Konaka +4 more
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2016
Dysregulation of the mitogen-activated protein kinase (MAPK) pathway has been associated with various neoplasms including melanomas. Common alterations in the MAPK pathway in melanomas include mutations in BRAF, EGFR, KIT, RAS, MEK, and ERK. The increased understanding of the biology and genetics of melanoma has generated interest in targeting the MAPK
Phyu P. Aung +2 more
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Dysregulation of the mitogen-activated protein kinase (MAPK) pathway has been associated with various neoplasms including melanomas. Common alterations in the MAPK pathway in melanomas include mutations in BRAF, EGFR, KIT, RAS, MEK, and ERK. The increased understanding of the biology and genetics of melanoma has generated interest in targeting the MAPK
Phyu P. Aung +2 more
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