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The MAPK signaling cascade

The FASEB Journal, 1995
The transmission of extracellular signals into their intracellular targets is mediated by a network of interacting proteins that regulate a large number of cellular processes. Cumulative efforts from many laboratories over the past decade have allowed the elucidation of one such signaling mechanism, which involves activations of ...
R, Seger, E G, Krebs
openaire   +3 more sources

Revisiting the role of MAPK signalling pathway in plants and its manipulation for crop improvement.

Plant, Cell and Environment, 2023
The mitogen-activated protein kinase (MAPK) pathway is an important signalling event associated with every aspect of plant growth, development, yield, abiotic and biotic stress adaptation.
M. Manna   +2 more
semanticscholar   +1 more source

Rice MAPKs

Biochemical and Biophysical Research Communications, 2003
Mitogen-activated protein kinase (MAPK) cascades are evolutionary conserved from unicellular to complex eukaryotic organisms, and constitute one of the major signalling pathways involved in regulating a wide range of cellular activities from growth and development to cell death.
Ganesh K, Agrawal   +2 more
openaire   +2 more sources

RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

Journal of Cellular Physiology, 2019
Mitogen‐activated protein kinase (MAPK) signaling pathways organize a great constitution network that regulates several physiological processes, like cell growth, differentiation, and apoptotic cell death.
Setareh Rezatabar   +10 more
semanticscholar   +1 more source

Compartmentalised MAPK Pathways

2008
The mitogen-activated protein kinase (MAPK) pathway provides cells with the means to interpret external signal cues or conditions, and respond accordingly. This cascade regulates many cell functions such as differentiation, proliferation and migration.
M D, Brown, D B, Sacks
openaire   +2 more sources

Defining MAPK Interactomes

ACS Chemical Biology, 2011
The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
openaire   +2 more sources

Analysis of MAPK Activities Using MAPK-Specific Antibodies

2014
Phosphorylation of proteins by mitogen-activated protein kinases is central to many cellular processes, including signal transduction after stress encounter. Thus, assays to identify or characterize MAP kinase activities are a key tool for research in this area. While in-gel kinase assays using isotope-labeled ATP are a powerful tool to investigate the
Roland, Willmann   +2 more
openaire   +2 more sources

Advancements in MAPK signaling pathways and MAPK‐targeted therapies for ameloblastoma: A review

Journal of Oral Pathology & Medicine, 2019
Numerous signal transduction pathways are closely associated with the occurrence, development, and prognosis of ameloblastoma (AM). Mitogen-activated protein kinase (MAPK) is a serine/threonine-specific protein kinase that transduces intracellular ...
Z. You   +4 more
semanticscholar   +1 more source

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