Results 201 to 210 of about 105,857 (302)

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Comparative analysis of different modalities of radiotherapy in vestibular schwannoma: tumor control, symptom evolution, and toxicity profiles. [PDF]

Strahlenther Onkol
Lishewski P, Fischer M, Tas KT, Sheikhzadeh FF, Smalec E, Agolli L, Nimsky C, Kemmling A, Habermehl D, Zink K, Gawish A, Adeberg S.   +11 more
europepmc   +1 more source

One Health Insights From Pteropus medius: Nipah Virus Spillover, Microbiota, and Antimicrobial Resistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Environmental and anthropogenic drivers of antibiotic resistance dissemination. The cycle reinforces how anthropogenic inputs, such as sewage, animal dung, hospital effluent, and agricultural runoff bring resistant bacteria and antibiotic residues into soil and water.
Punam Chowdhury, Shah Md Tanvir Khan, Sajal Roy, Md. Shohel Al Faruk   +3 more
wiley   +1 more source

Potential of large language models for rapid clinical information support: evidence from acute kidney injury knowledge testing. [PDF]

Sci Rep
Russ P, Bedenbender S, Einloft J, Meyer HL, Wenzel LT, Ganser A, Hirsch MC, Grgic I.   +7 more
europepmc   +1 more source

Symptom-based rehabilitation in people with post-COVID-19 condition (RELOAD study): a randomised controlled trial. [PDF]

BMJ Open Respir Res
Schneeberger T, Jarosch I, Kroll D, Gloeckl R, Schneider C, Ulm B, Schwaiblmair M, Lampert S, Greulich T, Schoenherr I, Schultz T, Schrag T, Dennis CJ, Koczulla AR.   +13 more
europepmc   +1 more source

A Comprehensive Evaluation of Adiposity Indices on 20‐Year Cumulative Incidence of Type 2 Diabetes: The ATTICA Cohort Study (2002–2022)

Clinical Obesity, Volume 16, Issue 4, August 2026.
ABSTRACT The aim of this study was to evaluate the association between indices of adiposity and 20‐year cumulative incidence of type 2 diabetes (T2D) among apparently healthy adults participating in the ATTICA cohort study (2002–2022). The present analysis included data from 2000 individuals free of atherosclerotic cardiovascular disease (ASCVD) and ...
Ioanna Kechagia, Sofia‐Panagiota Giannakopoulou, Fotios Barkas, Mary Yannakoulia, Evangelos Liberopoulos, Petros P. Sfikakis, Christos Pitsavos, Demosthenes Panagiotakos   +7 more
wiley   +1 more source

Infectious Disease Response in Tanzania: Enhanced Strategies From the 2023 to 2025 Marburg Outbreaks. [PDF]

Public Health Chall
Haque H, Rahim FO, Abbasi S, Nguyen N, Mahatara E, Jang A, Kapologwe NA.   +6 more
europepmc   +1 more source

Drivers of bat researchers’ intent to adopt field hygiene practices

Conservation Biology, Volume 40, Issue 4, August 2026.
Abstract Infectious disease is a growing threat to wildlife, with zoonotic transmission most likely at the human–wildlife interface. One underappreciated activity at this interface is fieldwork with wild animals, but associated risks can be mitigated through field hygiene (FH) practices, such as using personal protective equipment and other appropriate
Joanna L. Coleman, Ewan A. Macdonald, Abigail L. Rutrough, Tanja M. Straka, Todd D. Little, Zachary Stickley, Tigga Kingston   +6 more
wiley   +1 more source

Clinical, Dietary, Lifestyle and Genetic Factors Associated With Age at Onset of Esophageal Adenocarcinoma. [PDF]

United European Gastroenterol J
Koch V, Gockel I, Reingruber J, Kreuser N, Bigge J, Venerito M, Alakus H, May A, Gerges C, Thieme R, Heider D, Hillmer AM, Ebigbo A, Bruns CJ, Lang H, Messmann H, Rösch T, Wissniowski TT, Müller M, Denzer UW, Nöthen MM, Vieth M, Thrift AP, Maj C, Schumacher J.   +24 more
europepmc   +1 more source

Effectiveness of the school‐based internet intervention StresSOS for the prevention of mental health problems in young people: a randomized controlled trial as part of the ProHEAD consortium

Journal of Child Psychology and Psychiatry, Volume 67, Issue 8, Page 1393-1403, August 2026.
Background Given the high prevalence of mental illnesses in adolescents, there is an urgent need for effective prevention strategies. The aim of this study was to evaluate the school‐based internet intervention StresSOS for the universal prevention of mental illnesses in youth. Methods A two‐arm, randomized controlled trial was conducted.
Laya Lehner, Vera Gillé, Markus Moessner, Sabrina Baldofski, Stephanie Bauer, Katja Becker, Silke Diestelkamp, Alisa Hiery, Michael Kaess, Julian Koenig, Sophia Lustig, Christine Rummel‐Kluge, Rainer Thomasius, Heike Eschenbeck, the ProHEAD Consortium   +14 more
wiley   +1 more source