Results 41 to 50 of about 184,702 (284)

Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies

Advanced Healthcare Materials, EarlyView.
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer, Dolores J. Salander, Witold Szymanski, Johannes Graumann, Yukai Wang, Kai Zhao, Jörg W. Bartsch, María Gómez‐Serrano, Daniel Bachurski, Silke Reinartz, Elke von Pogge von Strandmann   +10 more
wiley   +1 more source

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

eLife
Marburg virus (MARV) is one of the filovirus species that cause deadly hemorrhagic fever in humans, with mortality rates up to 90%. Neutralizing antibodies represent ideal candidates to prevent or treat virus disease.
Yuting Zhang, Min Zhang, Haiyan Wu, Xinwei Wang, Hang Zheng, Junjuan Feng, Jing Wang, Longlong Luo, He Xiao, Chunxia Qiao, Xinying Li, Yuanqiang Zheng, Weijin Huang, Youchun Wang, Yi Wang, Yanchun Shi, Jiannan Feng, Guojiang Chen   +17 more
doaj   +1 more source

Shedding of Marburg Virus in Naturally Infected Egyptian Rousette Bats, South Africa, 2017

Emerging Infectious Diseases, 2020
We detected Marburg virus RNA in rectal swab samples from Egyptian rousette bats in South Africa in 2017. This finding signifies that fecal contamination of natural bat habitats is a potential source of infection for humans.
Janusz T. Pawęska, Nadia Storm, Wanda Markotter, Nicholas Di Paola, Michael R. Wiley, Gustavo Palacios, Petrus Jansen van Vuren   +6 more
doaj   +1 more source

Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008 [PDF]

, 2012
A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%).
A Grolla, A MacNeil, A Tuffs, AJ Georges, AM Casillas, B Jeffs, B Le Guenno, Benjamin Jeffs, BS Hewlett, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DH Smith, DL Heymann, E Mupere, ED Johnson, EM Leroy, EM Leroy, Esther Sterk, GA Martini, GA Martini, JL Conrad, Joseph Wamala, JS Gear, JS Towner, Julius Lutwama, K Kibadi, K Mupapa, K Mupapa, KJ Davis, M Borchert, M Bray, M Bray, MA Bwaka, Malcolm Gracie Semple, Maria D. Van Kerkhove, Matthias Borchert, ME Miranda, Michel Van Herp, MJ Bonnet, Natasha Howard, NK Jaax, P Formenty, P Formenty, P Francesconi, P Roddy, P Roddy, Paul Roddy, PE Rollin, Pedro Pablo Palma, PH Sureau, R Colebunders, R Ndambi, R Siegert, RC Baron, Robert Colebunders, RT Emond, S Becker, SF Dowell, SP Fisher-Hoch, SR Zaki, TH Roels, U Stroher, Y Kalongi, Zabulon Yoti   +66 more
core   +3 more sources

Biomarker-guided implementation of the KDIGO guidelines to reduce the occurrence of acute kidney injury in patients after cardiac surgery (PrevAKI-multicentre): protocol for a multicentre, observational study followed by randomised controlled feasibility trial [PDF]

, 2020
Introduction Acute kidney injury (AKI) is a frequent complication after cardiac surgery with adverse short-term and long-term outcomes. Although prevention of AKI (PrevAKI) is strongly recommended, the optimal strategy is uncertain.
Arndt, Christian, Campos, Sara, Cegarra Sanmartin, Virginia, Di Prima, Ambra, Forni, Lui, García Álvarez, Mercedes, Gerss, Joachim, Grau Novellas, Neus, Grieshaber, Philippe, Haffner, Michael, Honore, Patrick M, Hoste, Eric A J, Irqsusi, Marc, Italiano, Stefano, Kellum, John, Kunst, Gudrun, Küllmar, Mira, L'acqua, Camilla, Massoth, Christina, Meersch, Melanie, Monaco, Fabrizio, Nair, Shrijit, Ostermann, Marlies, Thomson, Gary, Universitat Autònoma de Barcelona, Vandenberghe, Wim, Weiss, Raphael, Wempe, Carola, Wulf, Hinnerk, Zarbock, Alexander   +29 more
core   +2 more sources

Randomized Comparison of Cardiotoxicity With 60 Versus 90 mg Daunorubicin in AML Induction Therapy

American Journal of Hematology, EarlyView.
Early cardiac biomarker monitoring in AML induction therapy showed significantly higher hsTnT levels after daunorubicin 90 mg/m2 compared with 60 mg/m2, indicating a dose‐dependent early myocardial effect. ABSTRACT Anthracyclines are an essential component of induction therapy for acute myeloid leukemia (AML), but their optimal dosing and the ...
Stefan Markus Dendorfer, Katharina Schmidt‐Brücken, Michael Kramer, Björn Steffen, Christoph Schliemann, Jan‐Henrik Mikesch, Nael Alakel, Regina Herbst, Mathias Hänel, Maher Hanoun, Martin Kaufmann, Barbora Weinbergerova, Kerstin Schäfer‐Eckart, Tim Sauer, Andreas Neubauer, Andreas Burchert, Claudia D. Baldus, Jolana Mertová, Edgar Jost, Dirk Niemann, Jan Novák, Stefan W. Krause, Sebastian Scholl, Andreas Hochhaus, Gerhard Held, Tomáš Szotkowski, Andreas Rank, Christoph Schmid, Lars Fransecky, Sabine Kayser, Markus Schaich, Frank Fiebig, Annett Haake, Johannes Schetelig, Jan Moritz Middeke, Friedrich Stölzel, Uwe Platzbecker, Christian Thiede, Carsten Müller‐Tidow, Wolfgang E. Berdel, Gerhard Ehninger, Jiri Mayer, Hubert Serve, Martin Bornhäuser, Christoph Röllig   +44 more
wiley   +1 more source

Serosurvey on Household Contacts of Marburg Hemorrhagic Fever Patients

Emerging Infectious Diseases, 2006
The first major outbreak of Marburg hemorrhagic fever (MHF) outside a laboratory environment occurred in the subdistrict of Watsa, Democratic Republic of Congo, from October 1998 to August 2000.
Matthias Borchert, Sabue Mulangu, Robert Swanepoel, Modeste Lifenya Libande, Antoine Tshomba, Amayo Kulidri, Jean-Jacques Muyembe-Tamfum, Patrick Van der Stuyft   +7 more
doaj   +1 more source

Marburg virus infection detected in a common African bat. [PDF]

PLoS ONE, 2007
Marburg and Ebola viruses can cause large hemorrhagic fever (HF) outbreaks with high case fatality (80-90%) in human and great apes. Identification of the natural reservoir of these viruses is one of the most important topics in this field and a ...
Jonathan S Towner, Xavier Pourrut, César G Albariño, Chimène Nze Nkogue, Brian H Bird, Gilda Grard, Thomas G Ksiazek, Jean-Paul Gonzalez, Stuart T Nichol, Eric M Leroy   +9 more
doaj   +1 more source

$S^6$ and the geometry of nearly K\"ahler $6$-manifolds

, 2017
We review results on and around the almost complex structure on $S^6$, both from a classical and a modern point of view. These notes have been prepared for the Workshop "(Non)-existence of complex structures on $S^6$" (\emph{Erste Marburger ...
Agricola, Ilka, Borówka, Aleksandra, Friedrich, Thomas   +2 more
core   +1 more source

Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health‐related quality of life and posing a safety hazard. Methods WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210 mg or placebo ...
Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose   +14 more
wiley   +1 more source