Results 51 to 60 of about 178,615 (281)

Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions. [PDF]

, 2008
The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks.
A.G. Sprecher, Anon., Baize, Basler, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Benjamin Jeffs, Bernard, Borchert, Bosio, Bosio, Boumandouki, Bray, Bray, Bray, Bray, Brummel-Ziedins, Bukreyev, Bwaka, CDC and WHO, Colebunders, Daddario-DiCaprio, Daniel G. Bausch, Dowell, Egbring, Emond, Enterlein, Feldmann, Formenty, Fourrier, Gear, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Gibbs, Gupta, Hensley, Hensley, Hensley, Hewlett, Hewlett, Hoenen, Hotchkiss, Huggins, Jahrling, Jahrling, Jahrling, Jeffs, Johnson, Jones, Jones, Khan, Ksiazek, Kudoyarova-Zubavichene, Larkin, Leroy, Leroy, Mahanty, Mahanty, Martin, Martini, Martini, Monath, Mupapa, Mupapa, Nikiforov, Oswald, Parrino, Pattyn, Paul Boumandouki, Peters, Peterson, Peterson, Pourrut, Reid, Rivers, Roberts, Rollin, Sanchez, Schnittler, Schuler, Smith, Spurgers, Stille, Sullivan, Sullivan, Swanepoel, Takada, Todorovitch, Towner, Warfield, Warfield, Warfield, Wilson, Zaki   +105 more
core   +2 more sources

Beyond the Edge: Charge‐Transfer Excitons in Organic Donor‐Acceptor Cocrystals

Advanced Functional Materials, EarlyView.
Complex excitonic landscapes in acene–perfluoroacene cocrystals are unveiled by polarization‐resolved optical spectroscopy and many‐body theory. This systematic study of a prototypical model system for weakly interacting donor–acceptor compounds challenges common views of charge‐transfer excitons, providing a refined conceptual framework for ...
Sebastian Anhäuser, Ana M. Valencia, Sergei I. Ivlev, Marc Zeplichal, Andreas Terfort, Caterina Cocchi, Gregor Witte   +6 more
wiley   +1 more source

Shedding of Marburg Virus in Naturally Infected Egyptian Rousette Bats, South Africa, 2017

Emerging Infectious Diseases, 2020
We detected Marburg virus RNA in rectal swab samples from Egyptian rousette bats in South Africa in 2017. This finding signifies that fecal contamination of natural bat habitats is a potential source of infection for humans.
Janusz T. Pawęska, Nadia Storm, Wanda Markotter, Nicholas Di Paola, Michael R. Wiley, Gustavo Palacios, Petrus Jansen van Vuren   +6 more
doaj   +1 more source

Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection. [PDF]

PLoS Pathogens, 2012
Marburg virus (family Filoviridae) causes sporadic outbreaks of severe hemorrhagic disease in sub-Saharan Africa. Bats have been implicated as likely natural reservoir hosts based most recently on an investigation of cases among miners infected in 2007 ...
Brian R Amman, Serena A Carroll, Zachary D Reed, Tara K Sealy, Stephen Balinandi, Robert Swanepoel, Alan Kemp, Bobbie Rae Erickson, James A Comer, Shelley Campbell, Deborah L Cannon, Marina L Khristova, Patrick Atimnedi, Christopher D Paddock, Rebekah J Kent Crockett, Timothy D Flietstra, Kelly L Warfield, Robert Unfer, Edward Katongole-Mbidde, Robert Downing, Jordan W Tappero, Sherif R Zaki, Pierre E Rollin, Thomas G Ksiazek, Stuart T Nichol, Jonathan S Towner   +25 more
doaj   +1 more source

A review of epidemiological parameters from Ebola outbreaks to inform early public health decision-making. [PDF]

, 2015
The unprecedented scale of the Ebola outbreak in West Africa has, as of 29 April 2015, resulted in more than 10,884 deaths among 26,277 cases. Prior to the ongoing outbreak, Ebola virus disease (EVD) caused relatively small outbreaks (maximum outbreak ...
Bento, AI, Donnelly, CA, Ferguson, NM, Mills, HL, Van Kerkhove, MD   +4 more
core   +1 more source

Biomarker-guided implementation of the KDIGO guidelines to reduce the occurrence of acute kidney injury in patients after cardiac surgery (PrevAKI-multicentre): protocol for a multicentre, observational study followed by randomised controlled feasibility trial [PDF]

, 2020
Introduction Acute kidney injury (AKI) is a frequent complication after cardiac surgery with adverse short-term and long-term outcomes. Although prevention of AKI (PrevAKI) is strongly recommended, the optimal strategy is uncertain.
Arndt, Christian, Campos, Sara, Cegarra Sanmartin, Virginia, Di Prima, Ambra, Forni, Lui, García Álvarez, Mercedes, Gerss, Joachim, Grau Novellas, Neus, Grieshaber, Philippe, Haffner, Michael, Honore, Patrick M, Hoste, Eric A J, Irqsusi, Marc, Italiano, Stefano, Kellum, John, Kunst, Gudrun, Küllmar, Mira, L'acqua, Camilla, Massoth, Christina, Meersch, Melanie, Monaco, Fabrizio, Nair, Shrijit, Ostermann, Marlies, Thomson, Gary, Universitat Autònoma de Barcelona, Vandenberghe, Wim, Weiss, Raphael, Wempe, Carola, Wulf, Hinnerk, Zarbock, Alexander   +29 more
core   +2 more sources

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

eLife
Marburg virus (MARV) is one of the filovirus species that cause deadly hemorrhagic fever in humans, with mortality rates up to 90%. Neutralizing antibodies represent ideal candidates to prevent or treat virus disease.
Yuting Zhang, Min Zhang, Haiyan Wu, Xinwei Wang, Hang Zheng, Junjuan Feng, Jing Wang, Longlong Luo, He Xiao, Chunxia Qiao, Xinying Li, Yuanqiang Zheng, Weijin Huang, Youchun Wang, Yi Wang, Yanchun Shi, Jiannan Feng, Guojiang Chen   +17 more
doaj   +1 more source

Marburg virus infection detected in a common African bat. [PDF]

PLoS ONE, 2007
Marburg and Ebola viruses can cause large hemorrhagic fever (HF) outbreaks with high case fatality (80-90%) in human and great apes. Identification of the natural reservoir of these viruses is one of the most important topics in this field and a ...
Jonathan S Towner, Xavier Pourrut, César G Albariño, Chimène Nze Nkogue, Brian H Bird, Gilda Grard, Thomas G Ksiazek, Jean-Paul Gonzalez, Stuart T Nichol, Eric M Leroy   +9 more
doaj   +1 more source

Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health‐related quality of life and posing a safety hazard. Methods WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210 mg or placebo ...
Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose   +14 more
wiley   +1 more source