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Marek's Disease Virus

1985
Publisher Summary Marek's disease (MD)—a malignant lymphomatosis in chickens—is caused by Marek's disease virus (MDV) of the family Herpesviridae. This chapter reviews recent advances in MD research, especially in the field of molecular biology. Various antigens present in MDV virions, MDV-infected cells, or MD lymphoma cells have been suspected as ...
S, Kato, K, Hirai
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Marek’s Disease Virus Latency

2001
MDV latency is defined as the persistence of the viral genome in the absence of production of infectious virus except during reactivation. A number of systems for studying MDV latency exist, and most involve the use of lymphoblastoid cells or tumors. It has been difficult to divorce latency and transformation.
R W, Morgan   +6 more
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Immune responses against Marek's disease virus

Animal Health Research Reviews, 2010
AbstractIt is more than a century since Marek's disease (MD) was first reported in chickens and since then there have been concerted efforts to better understand this disease, its causative agent and various approaches for control of this disease. Recently, there have been several outbreaks of the disease in various regions, due to the evolving nature ...
Payvand, Parvizi   +5 more
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Structural proteins of Marek's disease virus

Virology, 1972
Abstract Marek's disease virus (MDV) was propagated in roller-bottle cultures of duck embryo fibroblasts and partially purified by sucrose gradient centrifugation. Analysis of viral protein by polyacrylamide gel electrophoresis revealed that at least eight proteins (designated VPI-VPVIII) were present in MDV. The VPI is the major viral protein.
J H, Chen   +3 more
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Immunization against Marek's disease using Marek's disease virus‐specific antigens free from infectious virus

International Journal of Cancer, 1975
AbstractImmunity against Marek's disease was conferred by the use of non‐infectious materials extracted with non‐ionic detergents from cells infected with the attenuated strain of Marek's disease virus (MDV). Antibody‐free Rhode Island Red chicks were inoculated at 1 week of age with cell extracts emulsified in Freund's complete adjuvant and were given
F, Lesnik, L J, Ross
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Marek's Disease Virus in Commercial Turkey Flocks, Iran

Avian Diseases, 2023
Marek's disease is a significant illness in chickens and a potential threat to the poultry industry worldwide. Marek's disease virus (MDV) causes immunosuppression and lymphoproliferative disease in chickens, but the turkey is an unusual host for the virus, and tumors caused by MDV in turkeys are unique.
Hossein, Hosseini   +5 more
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A study of vaccination against Marek's disease with an attenuated Marek's disease virus

Avian Pathology, 1974
Approximately 2,000 day-old white leghorn chickens were distributed into 10 pens and half the pens vaccinated with the attenuated strain of HPRS-16. At 72 weeks of age, mortality from non-specific death and Marek's disease was 17.6% and 15.6% respectively, in vaccinated chickens compared with 14.2% and 51.7% in unvaccinated chickens.
C A, Jackson   +4 more
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Trials with Marek's disease vaccines prepared from a turkey herpes virus and an attenuated Marek's disease virus

Veterinary Record, 1975
In field trials involving over 224,000 fowls in 11 different commercial flocks, three vaccines were used, namely a freeze-dried vaccine prepared from a turkey herpes virus, a cell-associated virus vaccine prepared from the same isolate and a cell-associated vaccine prepared from a strain of Marek's disease virus isolated from a fowl. The mortality from
J D, Blaxland, A J, Macleod, T, Hall
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Isolation of Marek's disease virus: revisited

Avian Pathology, 2005
Splenocytes from chickens infected with low-passage stocks of Marek's disease virus (MDV) RB-1B, a very virulent (vv) strain and vv+ RK-1 were used to compare the efficacy of chick kidney cells (CKC), chicken embryo fibroblasts (CEF) and chicken embryo kidney cells (CEKC) for virus isolation. CKC were superior to CEF and CEKC.
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The Genomic Structure of Marek’s Disease Virus

2001
All herpesviruses contain linear, double-stranded DNA genome surrounded by a 100-nm diameter icosahedral protein capsid core consisting of 162 capsomers. In thin-section electron micrographs, an electron transparent region, termed the tegument, surrounds the capsid, which in turn is surrounded by a lipid-containing envelope.
R F, Silva, L F, Lee, G F, Kutish
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