Results 1 to 10 of about 52,393 (204)

HISTORY AND CURRENT STATUS OF MAREK'S DISEASE IN TURKEYS

German Journal of Veterinary Research, 2021
Marek’s disease (MD), caused by a highly contagious and oncogenic herpesvirus, causes immunosuppression and tumours in chickens. Although several reports on occurring lymphomas (MD-like conditions) in turkeys were published in the past less attention has
Awad Shehata, Dörte Lüschow, Hafez Hafez   +2 more
doaj   +1 more source

Efficient CRISPR-Cas9-mediated genome editing for characterization of essential genes in Trypanosoma cruzi

STAR Protocols, 2022
Summary: This protocol outlines a new genetic complementation strategy to investigate gene function in Trypanosoma cruzi, the parasite causing Chagas disease.
Gisele Fernanda Assine Picchi-Constante, Priscila Mazzocchi Hiraiwa, Martin Marek, Vanessa Zulkievicz Rogerio, Eloise Pavão Guerra-Slompo, Christophe Romier, Nilson Ivo Tonin Zanchin   +6 more
doaj   +1 more source

In cellulo and in vivo assays for compound testing against Trypanosoma cruzi

STAR Protocols, 2023
Summary: Here, we describe a combined in cellulo and in vivo approach to identify compounds with higher potential for efficient inhibition of Trypanosoma cruzi.
Eloise Pavão Guerra-Slompo, Gisele Fernanda Assine Picchi-Constante, Martin Marek, Christophe Romier, Wolfgang Sippl, Nilson Ivo Tonin Zanchin   +5 more
doaj   +1 more source

Pervasive Differential Splicing in Marek’s Disease Virus Can Discriminate CVI-988 Vaccine Strain from RB-1B Very Virulent Strain in Chicken Embryonic Fibroblasts

Viruses, 2020
Marek’s disease is a major scourge challenging poultry health worldwide. It is caused by the highly contagious Marek’s disease virus (MDV), an alphaherpesvirus.
Yashar Sadigh, Abdessamad Tahiri-Alaoui, Stephen Spatz, Venugopal Nair, Paolo Ribeca   +4 more
doaj   +1 more source

The survey on the circulation of Marek’s disease virus in local chickens in Tra Vinh province, Vietnam

Veterinary Integrative Sciences, 2023
The study was conducted to determine the circulation of Marek’s disease virus in local chickens in Tra Vinh province. A total of 343 feather follicle samples were collected from 49 unvaccinated chicken flocks for Marek disease in Tra Vinh City ...
Huynh Ngoc Trang, Nguyen Le Hung Phong, Nguyen Tran Phuoc Chien, Ho Thi Viet Thu   +3 more
doaj   +1 more source

Application of CRISPR/Cas9 Gene Editing System on MDV-1 Genome for the Study of Gene Function

Viruses, 2018
Marek’s disease virus (MDV) is a member of alphaherpesviruses associated with Marek’s disease, a highly contagious neoplastic disease in chickens.
Yaoyao Zhang, Na Tang, Yashar Sadigh, Susan Baigent, Zhiqiang Shen, Venugopal Nair, Yongxiu Yao   +6 more
doaj   +1 more source

Targeted Editing of the pp38 Gene in Marek’s Disease Virus-Transformed Cell Lines Using CRISPR/Cas9 System

Viruses, 2019
Marek’s disease virus (MDV), a lymphotropic α-herpesvirus associated with T-cell lymphomas in chickens, is an excellent model for herpesvirus biology and virus-induced oncogenesis.
Yaoyao Zhang, Jun Luo, Na Tang, Man Teng, Vishwanatha R.A.P. Reddy, Katy Moffat, Zhiqiang Shen, Venugopal Nair, Yongxiu Yao   +8 more
doaj   +1 more source

The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort. [PDF]

, 2018
ObjectiveThe Parkinson's Progression Markers Initiative (PPMI) is an observational, international study designed to establish biomarker-defined cohorts and identify clinical, imaging, genetic, and biospecimen Parkinson's disease (PD) progression markers ...
Arnedo, Vanessa, Caspell-Garcia, Chelsea, Chahine, Lana M, Chowdhury, Sohini, Coffey, Christopher S, Foroud, Tatiana, Frasier, Mark, Galasko, Doug, Jennings, Danna, Kieburtz, Karl, Lasch, Shirley, Marek, Kenneth, Mollenhauer, Brit, Parkinson's Progression Markers Initiative, Poston, Kathleen, Schuff, Norbert, Seibyl, John, Shaw, Leslie M, Sherer, Todd, Siderowf, Andrew, Simuni, Tanya, Singleton, Andrew, Tanner, Caroline M, Toga, Arthur W, Tosun-Turgut, Duygu, Trojanowski, John Q, Weintraub, Daniel   +26 more
core   +2 more sources

Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy [PDF]

, 2017
BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis ...
Afeltra, Antonella M. Vittoria, Amoroso, Antonio, Barbano, Biagio, Cianci, Rosario, Gigante, Antonietta, Margiotta, Domenico, Navarini, Luca, Rosato, Edoardo   +7 more
core   +1 more source

Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence.

PLoS Biology, 2020
Many livestock and human vaccines are leaky because they block symptoms but do not prevent infection or onward transmission. This leakiness is concerning because it increases vaccination coverage required to prevent disease spread and can promote ...
Richard I Bailey, Hans H Cheng, Margo Chase-Topping, Jody K Mays, Osvaldo Anacleto, John R Dunn, Andrea Doeschl-Wilson   +6 more
doaj   +1 more source