Results 41 to 50 of about 173,441,856 (300)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Interior point based optimal voltage stability, oscillatory stability and ATC margin boundary tracing [PDF]

, 2004
This dissertation proposes a general framework for the power system stability margin boundary tracing and optimization. The proposed framework combines interior point algorithm and continuation method seamlessly to provide the optimal control ...
Zhou, Zheng
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Escape of methane gas from the seabed along the West Spitsbergen continental margin [PDF]

, 2009
More than 250 plumes of gas bubbles have been discovered emanating from the seabed of the West Spitsbergen continental margin, in a depth range of 150-400 m, at and above the present upper limit of the gas hydrate stability zone (GHSZ).
Nisbet, Euan G., Crocker, A. J., Pälike, H, Pälike, H., Green, Darryl,, Beszczynska-Möller, Agnieszka, Westbrook, Graham, Osborne, AH, Green, D, Rohling, Eelco J., Fisher, R. E., Beszczynska-Möller, Alfred, Lanoisellé, M., Minshull, TA, Nisbet, EG, Chabert, A, Nisbet, E. G., Minshull, Tim A., Crocker, Anya J., Rohling, Eelco, Kuhnt, Wolfgang, James, RH, Berndt, C, Thatcher, Kate E., Piotrowski, A. M., Piotrowski, Alexander, Westbrook, G. K., Fisher, Rebecca E., Huhnerbach, Veit, Hühnerbach, V., Lanoisellé, M, Westbrook, Graham K., Aquilina, Alfred, Fisher, RE, Thatcher, Kate, Crocker, AJ, Gisbet, Euan G., Berndt, C., Bolton, Clara, Bolton, C, Green, D., James, Rachael H., Rohling, E. J., Green, Darryl, Osborne, Anne, Pälike, Heiko, Minshull, T. A., Aquilina, A, Beszczynska-Möller, A, Green, Darryl, R.H., James, R. H., Clemens, Steven, Osborne, Anne H., Green, Daryll, Chabert, A., Aquilina, A., Lanoisellé, Mathias, Bolton, C., Osborne, A. H., Rohling, EJ, Chabert, Anne, Berndt, Christian, Thatcher, K. E., Piotrowski, Alexander M., Piotrowski, AM, Beszczynska-Möller, A., Hühnerbach, V   +66 more
core   +1 more source

Impacts of obstacle-crossing during walking on postural control strategies in individuals with functional ankle instability

Frontiers in Bioengineering and Biotechnology
BackgroundLateral ankle sprains often progress to functional ankle instability (FAI). Obstacle-crossing could pose greater challenges for individuals with FAI due to significant impairments in ankle kinesthesia and joint position sense.
Ke Ma, Wenlong Zhou, Xiangwei Shi, Guodong Wang, Xiaokun Mao, Lingyu Kong, Qiuxia Zhang   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Minimum Margin of stability.

, 2015
Example margin of stability data for one subject during a) a Known left trial and b) an Unknown left trial. Left (L) and Right (R) minimum margin of stability (MOS), denoted by “x” marker at each step, is the minimum distance between the base of support (
Jesse H. Matsubara (769254), Keith E. Gordon (769255), Mengnan Wu (769253)   +2 more
core   +1 more source

Optimal Planning Method for Power System Line Impedance Based on a Comprehensive Stability Margin

IEEE Access, 2021
With the increasing scale of power systems and the large-scale application of new energy technologies, the planning and construction of future power grids and the stable operation of systems face severe challenges.
Dahu Li, Shuai Yang, Wentao Huang, Jun He, Zhijun Yuan, Jinman Yu   +5 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Assessment of Dynamic Stability During Walking in Below-knee Amputation

Physical Treatments, 2019
Purpose: Dynamic stability reduces in patients with unilateral amputation; so, it is important to recognize changes in balance during walking. This study aimed to investigate the dynamic stability of unilateral below-knee amputation during walking ...
Keyvan Sharifmoradi, Mostafa Kamali, Mohammad Taghi Karimi   +2 more
doaj