Results 51 to 60 of about 173,441,856 (300)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A comparative study of stability margins for walking machines [PDF]
Robotica, 2002 Several static and dynamic stability criteria have been defined in the course of walking robot history. Nevertheless, different applications may require different stability criteria and, to the authors' best knowledge, there is no qualitative classification of such stability measurements.
Elena Garcia +2 more
openaire +3 more sources
Bounded Linear Stability Margin Analysis of Nonlinear Hybrid Adaptive Control [PDF]
, 2008 This paper presents a bounded linear stability analysis for a hybrid adaptive control that blends both direct and indirect adaptive control. Stability and convergence of nonlinear adaptive control are analyzed using an approximate linear equivalent ...
Nguyen, Nhan T., Boskovic, Jovan D.
core
Voltage Stability Margin Estimation Using Machine Learning Tools [PDF]
, 2023 Real-time voltage stability assessment, via conventional methods, is a difficult task due to the required large amount of information, high execution times and computational cost.
Jaime Cepeda +11 more
core +1 more source
PLoS ONE, 2022 We investigated mediolateral dynamic stability at first foot off and first initial contact during gait initiation according to whether the paretic or non-paretic leg was used as the leading limb.
Yuji Osada +3 more
doaj +1 more source
IEEE Open Journal of the Industrial Electronics Society, 2021 Voltage-source rectifiers (VSRs) have been widely used in modern power grids. The inductive grid impedance of the power grid poses a serious threat to the stability of the VSR.
Kai Wang +3 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Dynamical velocity selection: Marginal stability
Physical Review Letters, 1987 Dee et al. have advanced the idea that the natural velocity of fronts propagating into an unstable state is related to the stability of these fronts through ``marginal stability.'' It is shown that this is indeed the case if front solutions lose stability through one particular mechanism. Marginal stability is derived for front propagation in the Swift-
openaire +5 more sources
Applied SciencesIndividuals with Parkinson’s disease (PD) have postural instability and gait dysfunction that lead to falls and disability with disease progression. Increased fall risk is particularly seen during challenging gait tasks such as obstacle-crossing.
Cathy Harro +6 more
doaj +1 more source