Results 41 to 50 of about 66,260 (210)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Evaluation of marginal and internal adaptation of implant-supported PEEK crowns fabricated by 3D printing, milling, and pressing: a micro-CT analysis

BMC Oral Health
Objectives This study aimed to evaluate and compare the marginal adaptation and internal gap of implant-supported crowns fabricated from polyetheretherketone (PEEK) using CAD-CAM milling, heat pressing, and 3D printing, employing non-destructive micro ...
Aliaa Ibrahim Mahrous, Mostafa El-Shazly, Mahitab Mansour, Alshaimaa Ahmed Shabaan, Mohamed Mokhtar, Ahmed Tawfik, Mohamed Mostafa Radwan   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Impact of finish line designs on the adaptation of ceramic fixed dental prostheses: a systematic review and network meta-analysis

BMC Oral Health
Background Insufficient marginal and internal adaptation can lead to secondary caries, pulp infection, periodontal disease, and tooth loss. This network meta-analysis (NMA) assessed the impact of various finish line designs on the marginal and internal ...
Adrienn Pál, Petra Papócsi, Kata Kelemen, Bianca Golzio Navarro Cavalcante , Péter Hegyi, Beáta Kerémi, Noémi Gede, Péter Hermann, Zoltán Géczi, Ivett Róth   +9 more
doaj   +1 more source

Dynamic Distribution Adaptation Based Transfer Network for Cross Domain Bearing Fault Diagnosis

Chinese Journal of Mechanical Engineering, 2021
In machinery fault diagnosis, labeled data are always difficult or even impossible to obtain. Transfer learning can leverage related fault diagnosis knowledge from fully labeled source domain to enhance the fault diagnosis performance in sparsely labeled
Yixiao Liao, Ruyi Huang, Jipu Li, Zhuyun Chen, Weihua Li   +4 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Marginal Seating of Zirconium Monolithic Crown Restorations Utilising Different Types of Luting Agents - A Comparative Study

Indian Journal of Dental Research
Background: Marginal adaptation plays a critical role in the clinical success of ceramic inlays, and several factors, including the type and composition of luting cement, can influence the marginal fit and overall integrity of restorations.
Zahraa M. Al-Hawwaz, Farah Adnan Taha, Adel F. Ibraheem, Lena S. Abdullah   +3 more
doaj   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source