Results 51 to 60 of about 412,183 (289)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Evaluation of Marginal Fit of Provisional Restoration Fabricated Using Tooth Moulding Acrylic Powder, Bisacryl Composite and 3D Printed Resin: An In-vitro Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Provisional restorations should have a good marginal fit with non impinging margins and ease of cleansability to protect the gingiva and periodontal tissues.
Priyanka Gopalakrishnan, Mathew Chalakuzhiyil Abraham, N Vidhyasankari, Sakthi Gnanavel Shanmugam, Vishnupriya Venkatasubramanian, Sindhuja Nagarajan   +5 more
doaj   +1 more source

The evaluation and comparison of marginal adaptation in metal ceramic and all ceramic restorations fabricated by two methods: CAD/CAM and conventional [PDF]

Journal of Dental Materials and Techniques, 2018
Introduction: Marginal fit is a key factor for long term clinical success through any dental restorations. Poor marginal adaptation causes cement dissolution.
Ahmad Ghahremanloo, Mohsen Movahedzadeh, Abdollah Javan Rashid   +2 more
doaj   +1 more source

Fighting Back: Human Adaptations in Marginal Environments

Environment: Science and Policy for Sustainable Development, 1999
Studies of the fragility of the natural environment often accord a prime role to human activities such as habitat destruction, land cover change, and "overuse" of biotic resources. One of the factors most closely associated with environmental degradation in the developing world is poverty.
Batterbury, Simon, Forsyth, Tim
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Adapting the Neural Encoder-Decoder Framework from Single to Multi-Document Summarization

, 2018
Generating a text abstract from a set of documents remains a challenging task. The neural encoder-decoder framework has recently been exploited to summarize single documents, but its success can in part be attributed to the availability of large parallel
Lebanoff, Logan, Liu, Fei, Song, Kaiqiang   +2 more
core   +1 more source

One-Dimensional Population Density Approaches to Recurrently Coupled Networks of Neurons with Noise [PDF]

, 2014
Mean-field systems have been previously derived for networks of coupled, two-dimensional, integrate-and-fire neurons such as the Izhikevich, adapting exponential (AdEx) and quartic integrate and fire (QIF), among others.
Campbell, Sue Ann, Ly, Cheng, Nicola, Wilten   +2 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluation of marginal and internal adaptation of implant-supported PEEK crowns fabricated by 3D printing, milling, and pressing: a micro-CT analysis

BMC Oral Health
Objectives This study aimed to evaluate and compare the marginal adaptation and internal gap of implant-supported crowns fabricated from polyetheretherketone (PEEK) using CAD-CAM milling, heat pressing, and 3D printing, employing non-destructive micro ...
Aliaa Ibrahim Mahrous, Mostafa El-Shazly, Mahitab Mansour, Alshaimaa Ahmed Shabaan, Mohamed Mokhtar, Ahmed Tawfik, Mohamed Mostafa Radwan   +6 more
doaj   +1 more source