Results 61 to 70 of about 409,525 (333)

Fighting Back: Human Adaptations in Marginal Environments

Environment: Science and Policy for Sustainable Development, 1999
Studies of the fragility of the natural environment often accord a prime role to human activities such as habitat destruction, land cover change, and "overuse" of biotic resources. One of the factors most closely associated with environmental degradation in the developing world is poverty.
Batterbury, Simon, Forsyth, Tim
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Impact of finish line designs on the adaptation of ceramic fixed dental prostheses: a systematic review and network meta-analysis

BMC Oral Health
Background Insufficient marginal and internal adaptation can lead to secondary caries, pulp infection, periodontal disease, and tooth loss. This network meta-analysis (NMA) assessed the impact of various finish line designs on the marginal and internal ...
Adrienn Pál, Petra Papócsi, Kata Kelemen, Bianca Golzio Navarro Cavalcante , Péter Hegyi, Beáta Kerémi, Noémi Gede, Péter Hermann, Zoltán Géczi, Ivett Róth   +9 more
doaj   +1 more source

Comparative Evaluation of Microleakage Between Nano-Ionomer, Giomer and Resin Modified Glass Ionomer Cement in Class V Cavities- CLSM Study [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Marginal integrity of adhesive restorative materials provides better sealing ability for enamel and dentin and plays an important role in success of restoration in Class V cavities.
Indira Priyadarshini Bollu, Archana Hari, Jayaprakash Thumu, Lakshmi Deepa Velagula, Nagesh Bolla, Sujana Varri, Srikanth Kasaraneni, Siva Venkata Malathi Nalli   +7 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Climate Policy and the Optimal Balance between Mitigation, Adaptation and Unavoided Damage [PDF]

It has become commonly accepted that a successful climate strategy should compound mitigation and adaptation. The accurate combination between adaptation and mitigation that can best address climate change is still an open question. This paper proposes a
Carlo Carraro, Enrica De Cian, Francesco Bosello   +2 more
core   +3 more sources

Marginal adaptation of direct and indirect restorations through digital radiographs: literature review [PDF]

RGO: Revista Gaúcha de Odontologia
The precise marginal adaptation in dental restorations and dental prosthesis is one of the essential requirements for success and longevity of rehabilitating treatments. Since the presence of marginal cracks can lead to exposure of cementing agent to the
Claudia Sanae Akita Shimoide Muraoka, Gisele Lie Fukuoka, Emily Freitas da Silva, Cláudio Costa   +3 more
doaj   +1 more source

Internal Adaptation and Marginal Gap of Split-File Versus Scanned Workflows of Three Types of Non-Metallic Super-Structures on Zirconia Abutments [PDF]

, 2022
Кhaled Elbanna, Alaa Alqutub
openalex   +1 more source

Margin-adaptive model selection in statistical learning

Bernoulli, 2011
A classical condition for fast learning rates is the margin condition, first introduced by Mammen and Tsybakov. We tackle in this paper the problem of adaptivity to this condition in the context of model selection, in a general learning framework.
Arlot, Sylvain, Bartlett, Peter
openaire   +4 more sources